香菊胶囊联合布地奈德鼻喷剂在慢性鼻窦炎术后的应用效果及其对IL-19、CXCL10、TSLP的影响  

Application of Xiangju capsules combined with budesonide nasal spray after operation of chronic sinusitis and its effect on IL-19,CXCL10,TSLP

作　　者：张金庄[1] 殷璞 刘宁[1] 王江宇 贾云芬 丁元吉[1] ZHANG Jin-zhuang;YIN Pu;LIU Ning(Department of Otolaryngology,Hebei Seventh People's Hospital(the Second Affiliated Hospital of Hebei University of Traditional Chinese Medicine),Dingzhou Hebei 073000,China;Operation Room,Dingzhou People's Hospital,Dingzhou Hebei 073000,China)

机构地区：[1]河北省第七人民医院(河北中医药大学第二附属医院)耳鼻喉科,河北定州073000 [2]定州市人民医院手术室,河北定州073000 [3]河北省第七人民医院(河北中医药大学第二附属医院)手术室,河北定州073000

出　　处：《临床和实验医学杂志》2024年第19期2105-2110,共6页Journal of Clinical and Experimental Medicine

基　　金：2020年度河北省医学科学研究课题(编号:20200214)。

摘　　要：目的观察香菊胶囊联合布地奈德鼻喷剂在慢性鼻窦炎术后的应用及其对白细胞介素(IL)-19、CXC趋化因子配体(CXCL)10、胸腺基质淋巴细胞生成素(TSLP)的影响。方法前瞻性选取2022年1月至2022年12月于河北省第七人民医院治疗的慢性鼻窦炎患者90例。按照随机数字表法将其分为观察组和对照组,每组各45例。对照组患者在慢性鼻窦炎术后给予布地奈德鼻喷剂治疗,观察组在对照组基础上给予香菊胶囊治疗。治疗3个月后,比较两组患者疗效、IL-19 mRNA及CXCL-10 mRNA的表达情况、TSLP的表达阳性率;分别于治疗前及治疗后3个月比较两组患者头痛、鼻漏、鼻塞等临床症状改善评分,Lund-Kennedy及Lund-Mackey评分;比较两组患者不良反应发生率及复发率。结果观察组总有效率为95.56%,高于对照组(82.22%),差异有统计学意义(P<0.05)。治疗3个月后,观察组IL-19 mRNA为5.06±1.08、低于对照组(9.63±2.93),CXCL-10 mRNA为0.0386±0.1269,高于对照组(0.0046±0.0127),差异均有统计学意义(P<0.05)。观察组TSLP表达阳性率为15.55%,低于对照组(33.33%),差异有统计学意义(P<0.05)。治疗3个月后,两组头痛、鼻漏及鼻塞临床症状评分均低于治疗前,且观察组各临床症状评分分别为(0.76±0.22)、(1.41±0.39)、(1.31±0.25)分,均低于对照组[(1.36±0.32)、(2.35±0.51)、(2.54±0.46)分],差异均有统计学意义(P<0.05)。治疗3个月后,两组Lund-Kennedy及Lund-Mackey评分均低于治疗前,且观察组Lund-Kennedy及Lund-Mackey评分分别为(1.94±0.32)、(2.18±0.31)分,均低于对照组[(3.04±0.42)、(3.34±0.54)分],差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。观察组复发率为2.22%,低于对照组(13.33%),差异有统计学意义(P<0.05)。结论香菊胶囊联合布地奈德鼻喷剂应用于慢性鼻窦炎术后的患者具有良好的临床疗效,且显著改善患者临床症状,降低IL-19 mRNA水�Objective To observe the effect of Xiangju capsules combined with budesonide nasal spray on interleukin(IL)-19,CXC chemokine ligand(CXCL)10,and thymic stromal lymphopoietin(TSLP)after chronic sinusitis.Methods The prospective study included 90 patients with chronic sinusitis who were treated in Hebei Seventh People's Hospital from January 2022 to December 2022.According to the random number table method,the observation group and the control group were divided into 45 cases in each group.The control group was treated with budesonide nasal spray after chronic sinusitis,and the observation group was treated with Xiangju capsules on the basis of the control group.The efficacy,IL-19mRNA and CXCL-10mRNA expression and positive rate of TSLP expression were compared after 3 months of treatment.The improvement scores of headache,rhinorrhea,nasal congestion and other clinical symptoms,Lund-Kennedy and Lund-Mackey scores were compared before and 3 months after treatment.The incidence and recurrence rate of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.56%,which was higher than that of the control group(82.22%),and the difference was statistically significant(P<0.05).After 3 months of treatment,the IL-19 mRNA in the observation group was 5.06±1.08,which was lower than that in the control group(9.63±2.93),and the CXCL-10 mRNA was 0.0386±0.1269,which was higher than that in the control group(0.0046±0.0127),the differences were statistically significant(P<0.05).The positive rate of TSLP expression in the observation group was 15.55%,which was lower than that in the control group(33.33%),and the difference was statistically significant(P<0.05).After 3 months of treatment,the clinical symptom scores of headache,rhinorrhea and nasal obstruction in the two groups were lower than those before treatment,and the clinical symptom scores in the observation group were(0.76±0.22),(1.41±0.39)and(1.31±0.25)points,respectively,which were lower than those in the

关 键 词：香菊胶囊 布地奈德鼻喷剂 慢性鼻窦炎 白细胞介素-19 CXC趋化因子配体10 胸腺基质淋巴细胞生成素 

分 类 号：R765.9[医药卫生—耳鼻咽喉科]