H_(2)O_(2)-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors  

作　　者：Jian Wang Ke Liang Jian Li Yun-Xiu Zhang Xiao-Kuang Xue Tie-Jin Chen Yong-Liang Hao Jia-Sheng Wu Jie-Chao Ge 

机构地区：[1]Key Laboratory of Photochemical Conversion and Optoelectronic Materials,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing,100190,China [2]School of Future Technology,University of Chinese Academy of Sciences,Beijing,100049,China

出　　处：《Chinese Journal of Polymer Science》2024年第11期1690-1698,I0008,共10页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.52272052 and 51972315)。

摘　　要：Photodynamic therapy(PDT)has been emerged as a promising modality for cancer treatment.However,the development of drug delivery system enabling continuous release of photosensitizers(PSs)for long-term PDT treatment still remains challenges.Herein,a H_(2)O_(2)-responsive injectable hydrogel,covalently crosslinked by N^(1)-(4-boronobenzyl)-N^(3)-(4-boronophenyl)-N^(1),N^(1),N^(3),N^(3)-tetramethylpropane-1,3-diaminium(TSPBA)with PVA containing polythiophene quaternary ammonium salt(PT2)polymer dots(PDots)as a photosensitizer was fabricated.Under the stimulation of H_(2)O_(2),the obtained injectable hydrogel gradually degrades and releases PDots.In vitro experiments suggested that the released PDots could realize efficient tumor cells inhibition through its robust singlet oxygen generation capability upon 577 nm laser irradiation.In vivo studies demonstrated a sustained retention of PDots for at least 7 days following single-dose administration,facilitating efficient tumor inhibition with light treatments for 3 times without apparent biotoxicity.This work presents an innovative polymer dots-based composite local drug delivery system for long-term PDT in cancer treatment.

关 键 词：Injectable hydrogel Polymer dots Photodynamic therapy LONG-TERM Cancer therapy 

分 类 号：TB332[一般工业技术—材料科学与工程]