登革热疫苗与抗病毒药物研究进展  

Research advances in development of vaccines and antiviral drugs for dengue fever

作　　者：段曰黎 周晛 王新宇 Duan Yueli;Zhou Xian;Wang Xinyu(Department of Infectious Diseases,Huashan Hospital Affiliated to Fudan University,Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response,National Medical Center for Infectious Diseases,Shanghai 200040,China)

机构地区：[1]腾冲市人民医院感染科,腾冲679100 [2]复旦大学附属华山医院感染科,上海市传染病与生物安全应急响应重点实验室,国家传染病医学中心,上海200040

出　　处：《中华临床感染病杂志》2024年第4期312-320,共9页Chinese Journal of Clinical Infectious Diseases

基　　金：上海市第六轮公共卫生体系建设三年行动计划(2023-2025年)传染病学重点学科建设项目(GWⅥ-11.1-13)。

摘　　要：登革热是由登革病毒引起的一种急性病毒性传染病,在全球热带和亚热带地区出现暴发流行,已经成为全球卫生的重要负担和健康威胁。登革热疫苗和抗病毒药物的研究正在快速推进。现有的CYD-TDV疫苗主要适用于既往感染者,而TAK-003和Butantan-DV等疫苗,已经在不同年龄段和未感染者中显示出了很好的安全性和有效性;其他多种不同类型的登革热疫苗也已经进入了临床研究。在登革热抗病毒药物方面也已经取得了明显的进展,其中JNJ-1802作为一种口服抗病毒药物,在临床试验中显示出对登革病毒较强的抗病毒活性和良好的耐受性,目前已进入社区实地研究阶段,以验证其在真实环境中的效果;其余多款药物也在不断研发中。本文就登革热疫苗和抗病毒药物研究进展进行介绍,希望帮助减轻全球登革热的负担,提高公共健康水平。Dengue fever,caused by the dengue virus,is an acute viral infectious disease,which frequently outbreaks in tropical and subtropical regions worldwide,and has become a significant global health burden and threat.The development of dengue vaccines and antiviral drugs has made rapid and significant progress recently.The existing CYD-TDV vaccine is primarily suitable for individuals prior infection,while vaccines such as TAK-003 and Butantan-DV have demonstrated good safety and efficacy in uninfected individuals of different age groups;several other types of dengue vaccines have also entered clinical research stages.For antiviral drugs,an oral antiviral drug JNJ-1802 has shown significant antiviral activity against the dengue virus and good tolerability in clinical trials.It has now entered community field research to validate its effectiveness in real-world settings.Several other drugs are also under continuous development.This article reviews the research progress in the development of vaccines and antiviral drugs for dengue fever to provide reference for further study and clinical application.

关 键 词：登革热 登革病毒 疫苗 抗病毒药物 

分 类 号：R392-33[医药卫生—免疫学] R978.7[医药卫生—基础医学]