甘肃省孕妇妊娠期疫苗接种与早产关联性的真实世界数据配对病例对照研究  

Association of vaccination in pregnancy with preterm birth among pregnant women:a matched case-control study using real-world data in Gansu province

作　　者：梁雪枫[1] 刘舒瑜[1] 彭娟霞 孙迪 张秉玲[1] 安婧[1] 唐宇[1] 张晓曙[1] Liang Xuefeng;Liu Shuyu;Peng Juanxia;Sun Di;Zhang Bingling;An Jing;Tang Yu;Zhang Xiaoshu(Gansu Provincial Center for Disease Control and Prevention,Lanzhou 730000,Gansu,China)

机构地区：[1]甘肃省疾病预防控制中心,甘肃兰州730000

出　　处：《中国疫苗和免疫》2024年第5期526-530,共5页Chinese Journal of Vaccines and Immunization

基　　金：甘肃省卫生健康行业科研计划(GSWSKY2023-21,GSWSKY2023-36)。

摘　　要：目的探讨孕妇妊娠期疫苗接种与早产的关联性。方法采用1∶2匹配病例对照研究,通过甘肃省电子病历系统和预防接种信息管理系统收集2018-2023年分娩孕妇的早产和妊娠期疫苗接种信息,以早产孕妇为病例组,选择分娩年龄、户籍和文化程度相同的足月分娩孕妇为对照组,采用Logistic回归模型分析疫苗接种与早产之间的调整比值比(Odds ratio,OR)及其95%置信区间(Confidence interval,CI)。结果在40849例病例组和81698例对照组研究对象中,乙型肝炎疫苗、流感疫苗、人乳头瘤病毒疫苗、肾综合征出血热疫苗、狂犬病疫苗接种比例分别为0.26%vs 0.23%、0.24%vs 0.27%、0.14%vs 0.10%、0.01%vs 0.02%、0.11%vs 0.11%,相应疫苗接种与早产之间的调整OR(95%CI)分别为1.15(0.91-1.47)、0.86(0.68-1.10)、1.40(1.00-1.96)、0.63(0.23-1.73)、1.01(0.70-1.46)。结论本研究提示孕妇妊娠期相关疫苗接种未增加早产的发生风险。Objective To explore the association of vaccination in pregnancy with preterm birth among pregnant women.Methods We conducted a 1∶2 matched case-control study in which data on preterm birth and vaccination of pregnant women who delivered in 2018-2023 were obtained from the Electronic Medical Record System and the Immunization Information Management System in Gansu province.Cases were women with preterm birth outcomes;controls were women with term birth outcomes who were matched with cases by age at delivery,household registration,and education level.We calculated adjusted odds ratios(OR)and 95%confidence intervals(CI)for the association between vaccination and preterm birth using a logistic regression model.Results Among 40849 cases and 81698 controls,0.26%vs 0.23%,0.24%vs 0.27%,0.14%vs 0.10%,0.01%vs 0.02%,and 0.11%vs 0.11%had received hepatitis B vaccine,influenza vaccine,human papillomavirus vaccine,hemorrhagic fever with renal syndrome vaccine,or rabies vaccine,respectively.Adjusted ORs(95%CI)for the association between vaccination and preterm birth were 1.15(0.91-1.47),0.86(0.68-1.10),1.40(1.00-1.96),0.63(0.23-1.73),and 1.01(0.70-1.46).Conclusion Vaccination in pregnancy was not associated with increased risk of preterm birth.

关 键 词：妊娠期疫苗接种 早产 孕妇 配对病例对照研究 

分 类 号：R186[医药卫生—流行病学]