自身对照病例系列研究及其在疫苗不良事件因果关联评价中的应用  

Self-controlled case series studies and their application for evaluating causal association between a vaccine and an adverse event

作　　者：李媛 李克莉[1,2] 李燕[1,2] 任敏睿 张丽娜 樊春祥[1,2] 余文周[1,2] 尹遵栋[1,2] Li Yuan;Li Keli;Li Yan;Ren Minrui;Zhang Lina;Fan Chunxiang;Yu Wenzhou;Yin Zundong(National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Beijing 102206,China;National Immunization Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China)

机构地区：[1]传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心,北京102206 [2]中国疾病预防控制中心免疫规划中心,北京100050

出　　处：《中国疫苗和免疫》2024年第5期603-607,共5页Chinese Journal of Vaccines and Immunization

基　　金：新冠灭活疫苗应用与免疫策略(2021YFC2301600);中国疾病预防控制中心公共卫生应急反应机制的运行(102393220020010000017)。

摘　　要：自身对照病例系列研究(Self-controlled case series study,SCCS)是一种只需要病例信息且以病例自身为对照,研究瞬时暴露与事件之间关联性的流行病学研究。SCCS最初用于评估疫苗安全性,可以比较快速地获得疫苗与不良事件之间的潜在因果关联。本文总结了SCCS的原理、研究设计和常见问题的解决思路。A self-controlled case series study(SCCS)is an epidemiological study that requires only cases and uses the cases themselves as their controls to determine the association between a transient exposure and an adverse event.SCCSs were originally used to evaluate vaccine safety,allowing for relatively rapid evaluation of potential causal associations between a vaccine and an adverse event.In this article,we summarize the principles,research design,and solutions for common problems in SCCSs.

关 键 词：自身对照病例系列研究 原理 设计 疫苗 不良事件 因果关联性 

分 类 号：R186[医药卫生—流行病学]