带状疱疹后神经痛发病机制的研究进展  

Research progresses of the mechanisms in postherpetic neuralgia

作　　者：李敏[1] 胡焓[1] 张书力[1] 童胜雄[1] 袁峰[1] 田佳玉[1] 李少军 冯丹[1] Li Min;Hu Han;Zhang Shuli;Tong Shengxiong;Yuan Feng;Tian Jiayu;Li Shaojun;Feng Dan(Department of Painology,First Hospital of Wuhan,Wuhan City,Hubei Province 430022,China)

机构地区：[1]武汉市第一医院疼痛科,武汉市430022

出　　处：《中华疼痛学杂志》2024年第4期628-632,共5页Chinese Journal Of Painology

摘　　要：带状疱疹后神经痛(PHN)的疼痛难以控制,治疗效果较为局限,严重降低了患者生活质量。PHN发病机制复杂,水痘-带状疱疹病毒(VZV)感染与再激活、外周神经损伤及中枢敏化等多种机制均参与其中。本文对近年来PHN发病机制的最新研究进展进行综述,为PHN临床治疗提供理论依据。Postherpetic neuralgia(PHN)is difficult to control and reduce patients'quality of life.The pathogenesis of PHN is complex.Varicella-zoster virus(VZV)infection and reactivation,peripheral nerve injury and central sensitization and other mechanisms are involved.In this paper,the latest research progresses of the mechanisms in PHN are reviewed to provide a theoretical basis for the clinical treatment of PHN.

关 键 词：神经痛 带状疱疹后 发病机制 进展 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]