SPECT/CT定量技术在骨骼疾病中临床研究进展  

Advances in clinical research of SPECT/CT quantitative techniques in skeletal diseases

作　　者：马旭 王雪梅[1] Ma Xu;Wang Xuemei(Department of Nuclear Medicine,Inner Mongolia Medical University Affiliated Hospital,Inner Mongolia Key Laboratory of Molecular Imaging,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院核医学科,内蒙古分子影像学重点实验室,呼和浩特010050

出　　处：《国际放射医学核医学杂志》2024年第8期515-522,共8页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家重点研发计划"诊疗装备与生物医用材料"重点专项(2022YFC2403804)

摘　　要：以往SPECT对疾病的诊断评估主要停留在定性或半定量水平。随着SPECT显像结合CT和图像重建技术的发展,SPECT能够以类似PET的方式进行定量评估并已应用于人体的循环、内分泌、神经与骨骼多个系统。SPECT显像能早期灵敏地检测骨骼代谢功能的异常,在骨转移瘤形成的初始阶段未出现骨骼解剖结构的变化时灵敏地检测出骨转移瘤,是目前检测骨转移瘤应用最广泛的显像方式。随着SPECT显像技术的发展,SPECT/CT融合显像可以通过衰减校正技术与融合CT解剖结构图像提高骨扫描的特异度。传统SPECT/CT通过病灶对示踪剂的摄取进行主观的视觉评估,使用SPECT/CT定量参数可对骨骼病灶进行客观准确的评估。SPECT/CT定量技术的发展已受到普遍关注,笔者结合国内外相关临床研究结果,论述SPECT/CT定量技术的定量方法及其在骨骼系统疾病中的研究进展,期望定量方法能应用于SPECT/CT诊断的更多领域,并建立相关标准。In the past,the diagnostic evaluation of diseases by SPECT was mainly at the qualitative or semi-quantitative level.With the development of SPECT imaging combined with CT and image reconstruction techniques,SPECT has been able to perform quantitative assessments in a manner similar to PET and has been applied to the circulatory,endocrine,neurological and skeletal systems of the human body.SPECT imaging is the most widely used imaging method for detecting bone metastases because it can sensitively detect abnormalities in the metabolic function of bones at an early stage,and sensitively detect bone metastases at the initial stage of bone metastases formation when there are no changes in the skeletal anatomical structure.With the development of SPECT imaging techniques,SPECT/CT fusion imaging can improve the specificity of bone scans by attenuation correction techniques with fused CT anatomical structure images.While conventional SPECT/CT provides a subjective visual assessment by lesion uptake of tracer,the use of quantitative SPECT/CT parameters allows for an objective and accurate assessment of skeletal lesions.The development of SPECT/CT quantitative technology has received general attention.Combining the results of relevant clinical studies at home and abroad,the authors discusse the quantitative methods of SPECT/CT quantitative technology and its research progress in skeletal system diseases,expecting that the quantitative methods can be applied to more fields of SPECT/CT diagnosis,and establishing relevant criteria.

关 键 词：体层摄影术 发射型计算机 单光子 体层摄影术 X线计算机 标准化摄取值 骨骼疾病 定量方法 

分 类 号：R817.4[医药卫生—影像医学与核医学] R681[医药卫生—放射医学]