Comparisons of frozen-thawed D3/D5 and D3/D6 sequential embryo transfer in women with repeated implantation failure:a retrospective cohort study  

作　　者：Zheng Wang Jiangman Gao Xiaoyu Long Rong Li 

机构地区：[1]Center for Reproductive Medicine,Peking UniversityThird Hospital,Beijing,China [2]National Clinical Research Center for Obstetrics and Gynecology,Peking University Third Hospital,Beijing,China [3]State Key Laboratory of Female Fertility Promotion,Peking University Third Hospital,Beijing,China [4]Key Laboratory of Assisted Reproduction,Peking University,Ministry of Education,Beijing,China [5]SBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology,Peking University Third Hospital,Beijing,China

出　　处：《Gynecology and Obstetrics Clinical Medicine》2024年第3期143-152,共10页妇产科临床医学（英文）

基　　金：supported by Capital's Funds for Health Improvement and Research(CFH2024-2-40910).

摘　　要：Objective To investigate whether there are significant differences in pregnancy outcomes between frozen-thawed D3/D5 and D3/D6 sequential embryo transfer(SeET)in women with repeated implantation failure(RIF).Methods Women who experienced RIF and underwent frozen-thawed cycles with SeET were included and were divided into two groups:D3/D5(n=455)and D3/D6(n=308).Included cycles were stratified by the quality of transferred embryos and age.Results There were 252/455(55.4%)clinical pregnancies in the D3/D5 group and 133/308(43.2%)in the D3/D6 group(OR:1.63,95%CI1.22 to 2.18).Rates for ectopic pregnancy,early miscarriage and multiple pregnancies did not differ between the two groups.In women under 35 years,with transfers of two good-quality embryos,the clinical pregnancy rate was significantly higher in the D3/D5 group compared with the D3/D6 group(65.6%vs 42.4%,OR:2.59,95%CI1.41 to 4.76).This trend persisted when analysing good-quality cleavage-stage embryo and poor-quality blastocyst(D3/D5)transfers versus two good-quality embryo(D3/D6)transfers(61.2%vs 42.4%,OR:2.14.95%CI1.11 to 4.12).For women aged 35 years or older,pregnancy outcomes did not differ.Conclusion The clinical pregnancy rate was significantly higher in the D3/D5group compared with the D3/D6 group.When contrasting the outcomes of transferring a good-quality cleavage-stage embryo and a poor-quality blastocyst in the D3/D5 group with transferring two good-quality embryos in the D3/D6 group,the clinical pregnancy rate was significantly higher in the D3/D5 group.However,among women aged 35 years or older,there were no significant differences in pregnancy outcomes.

关 键 词：IMPLANTATION TRANSFER FROZEN 

分 类 号：R71[医药卫生—妇产科学]