间充质干细胞分泌IL-6调控巨噬细胞表型及其在炎症性疾病和肿瘤中的作用  

Mesenchymal Stem Cells Regulation of Macrophage Phenotype by Secreting IL-6 and Its Role in Inflammatory Diseases and Tumors

作　　者：刘慧 刘磊[1,3] 张君 武艳[2] 李全海[1,3] LIU Hui;LIU Lei;ZHANG Jun;WU Yan;LI Quanhai(Cell Therapy Laboratory,the First Hospital of Hebei Medical University,Shijiazhuang 050000,China;Inspection Center,the First Hospital of Hebei Medical University,Shijiazhuang 050000,China;Large-Scale Scientific Research Instruments and Equipment Sharing Service Platform,Institute of Medicine and Health,Hebei Medical University,Shijiazhuang 050017,China)

机构地区：[1]河北医科大学第一医院细胞治疗实验室,石家庄050000 [2]河北医科大学第一医院检验中心,石家庄050000 [3]河北医科大学医学与健康研究院大型科研仪器设备共享服务平台,石家庄050017

出　　处：《医学综述》2024年第23期2817-2823,共7页Medical Recapitulate

基　　金：河北省自然科学基金(重点项目)(C2020206032);河北省省直医疗机构老年病防治项目(LNB202108);河北省政府资助临床医学优秀人才培养项目(ZF2023030)。

摘　　要：间充质干细胞(MSCs)是一种对免疫细胞具有调控作用的成体干细胞。它可调节促炎M1型巨噬细胞向抗炎M2型巨噬细胞极化,从而发挥缓解炎症的生物学效应。在调控巨噬细胞的过程中,MSCs分泌了诸多细胞因子,其中白细胞介素-6(IL-6)发挥重要作用。一方面,IL-6通过抑制炎症进展参与炎症反应;另一方面,其通过活化M2型巨噬细胞极化的信号通路促进肿瘤侵袭转移。未来深入研究MSCs与IL-6对巨噬细胞的调控作用,有助于为炎症性疾病和恶性肿瘤的治疗提供新思路及策略。Mesenchymal stem cells(MSCs)are adult stem cells that can regulate immune cells.It can regulate the polarization of pro-inflammatory M1-type macrophages to anti-inflammatory M2-type macrophages,thus exerting the biological effect of relieving inflammation.In the process of regulating macrophages,MSCs secrete many cytokines,among which interleukin-6(IL-6)plays an important role.On the one hand,IL-6 participates in inflammatory reaction by inhibiting the inflammation progression;on the other hand,it promotes tumor invasion and metastasis by activating the polarization signaling pathway of M2 macrophages.In the future,in-depth research on the regulatory effects of MSCs and IL-6 on macrophages will help provide new ideas and strategies for the treatment of inflammatory diseases and malignant tumors.

关 键 词：炎症性疾病 肿瘤 间充质干细胞 白细胞介素-6 巨噬细胞极化 

分 类 号：R392[医药卫生—免疫学]