载脂蛋白E基因多态性与急性冠状动脉综合征关系的研究进展  

Research Progress of Relationship between Apolipoprotein E Gene Polymorphism and Acute Coronary Syndrome

作　　者：王佳 李晓东 王雪森 杨晓鹤 高美丽 张辰浩[1] WANG Jia;LI Xiaodong;WANG Xuesen;YANG Xiaohe;GAO Meili;ZHANG Chenhao(Department of Emergency,Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing 100102,China;Department of Emergency,Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital,Beijing 101300,China)

机构地区：[1]中国中医科学院望京医院急诊科,北京100102 [2]北京中医医院顺义医院急诊科,北京101300

出　　处：《医学综述》2024年第23期2928-2932,共5页Medical Recapitulate

基　　金：首都卫生发展科研专项重点攻关项目(首发2022-1-4161);中国中医科学院望京医院自主选题专项课题(WJYY-ZZXT-2022-12)。

摘　　要：急性冠状动脉综合征(ACS)是由不稳定的冠状动脉粥样硬化斑块(AP)破裂或糜烂导致血栓形成而引发的一系列缺血性疾病,其病理基础为AP形成,这一过程受到脂质代谢紊乱的驱动。血脂水平是ACS预后的关键因素,载脂蛋白E(ApoE)作为脂质代谢的关键调控因子,其多态性与血脂异常密切相关。而ApoE4基因型患者ACS后强化他汀治疗效果不佳是ACS的独立危险因素。未来明确ApoE基因多态性与ACS的关系,有助于为ACS患者制订个体化降脂方案提供更为精准、安全的策略。Acute coronary syndrome(ACS)is a series of ischemic diseases caused by the rupture or erosion of unstable coronary atherosclerotic plaque(AP)leading to thrombosis.The pathological basis of ACS is the formation of AP,which is driven by the disorder of lipid metabolism.Blood lipid level is a key factor for the prognosis of ACS,and apolipoprotein E(ApoE),as a key regulator of lipid metabolism,its polymorphism is closely related to dyslipidemia.The poor efficacy of intensified statin therapy after ACS in ApoE4 genotype patients is an independent risk factor for ACS.In the future,clarifying the correlation of ApoE gene polymorphism with ACS will help to provide more accurate and safe strategies to develop individualized lipid-lowering programs for ACS patients.

关 键 词：急性冠状动脉综合征 血脂异常 载脂蛋白E 基因多态性 

分 类 号：R541.4[医药卫生—心血管疾病]