甲苯磺酸奥马环素片与盐酸莫西沙星片治疗社区获得性细菌性肺炎的疗效及安全性比较  

Comparison of the efficacy and safety of omadacycline tosylate tablets and moxifloxacin hydrochloride tablets in the treatment of community-acquired bacterial pneumonia

作　　者：张勇 Zhang Yong(Zhangjiagang Sixth People’s Hospital,Zhangjiagang,Jiangsu 215625,China)

机构地区：[1]江苏省张家港市第六人民医院,江苏张家港215625

出　　处：《首都食品与医药》2024年第21期81-83,共3页Capital Food Medicine

摘　　要：目的比较甲苯磺酸奥马环素片与盐酸莫西沙星片在社区获得性细菌性肺炎患者中的应用价值。方法将186例于2023年3月-2024年3月在张家港市第六人民医院诊治的社区获得性细菌性肺炎患者按照数字抽签法随机分为A、B两组,每组93例,除基础的对症治疗外,A组以甲苯磺酸奥马环素片为抗菌药,B组以盐酸莫西沙星片为抗菌药,对两组治疗后临床效果、病情相关评分[肺炎严重指数(PSI)及肺炎病情严重程度评分系统(SMART-COP)评分]、炎性因子水平[白介素-6(IL6)、降钙素原(PCT)、C-反应蛋白(CRP)]及治疗安全性进行比较。结果治疗总有效率A组为95.70%(89/93),高于B组的87.10%(81/93);治疗后,A组PSI评分、SMART-COP评分及血清IL-6、PCT、CRP水平低于B组,以上差异均有统计学意义(P<0.05)。不良反应发生率A组为8.60%(8/93),与B组的11.83%(11/93)比较,差异无统计学意义(P>0.05)。结论甲苯磺酸奥马环素片与盐酸莫西沙星片均是治疗社区获得性细菌性肺炎安全、有效药物,但甲苯磺酸奥马环素片疗效更为显著,能更有效改善病情,下调炎性因子水平。Objective To compare the application value of omadacycline tosylate tablets and moxifloxacin hydrochloride tablets in patients with community-acquired bacterial pneumonia.Methods A total of 186 patients with community-acquired bacterial pneumonia who were diagnosed and treated in the Sixth People’s Hospital of Zhangjiagang City from March 2023 to March 2024 were randomly divided into two groups,A and B,with 93 cases in each group,in addition to the basic symptomatic treatment,group A was treated with omadacycline tosylate tablets as antibacterial drugs,and group B was treated with moxifloxacin hydrochloride tablets as antibacterial drugs.Pneumonia severity index(PSI)and pneumonia severity scoring system(SMART-COP)score,inflammatory factor levels[interleukin-6(IL-6),procalcitonin(PCT),C-reactive protein(CRP)]and treatment safety were compared.Results The total effective rate of treatment in group A was 95.70%(89/93),which was higher than that in group B 87.10%(81/93).After treatment,the PSI score and SMART-COP score in group A were lower than those in group B.After treatment,the serum levels of IL-6,PCT and CRP in group A were lower than those in group B.The above differences were statistically significant(P<0.05).The incidence of adverse reactions in group A was 8.60%(8/93),which was not statistically significant compared with 11.83%(11/93)in group B(P>0.05).Conclusion Omadacycline tosylate tablets and moxifloxacin hydrochloride tablets are both safe and effective drugs for the treatment of community-acquired bacterial pneumonia,but omadacycline tosylate tablets have more significant efficacy,which can more effectively improve the condition and downregulate the level of inflammatory factors.

关 键 词：社区获得性肺炎 细菌感染 甲苯磺酸奥马环素片 盐酸莫西沙星片 

分 类 号：R563.1[医药卫生—呼吸系统]