原发性高血压患者血浆致动脉粥样硬化指数与左心室肥厚的相关性研究  

Relationship Between Plasma Atherogenic Index and Left Ventricular Hypertrophy in Patients with Primary Hypertension

作　　者：翟玉梅 岳建伟 王子超 ZHAI Yumei;YUE Jianwei;WANG Zichao(The Second Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014030 China)

机构地区：[1]内蒙古科技大学包头医学院第二附属医院,内蒙古包头014030

出　　处：《内蒙古医学杂志》2024年第10期1168-1173,共6页Inner Mongolia Medical Journal

摘　　要：目的分析原发性高血压患者血浆致动脉粥样硬化指数(AIP)与左心室肥厚(LVH)的相关性。方法选取2022年1—12月包头医学院第二附属医院心血管内科收治的高血压患者作为研究对象。根据左心室质量指数进行分类,分为左心室肥厚组(L VH组)和非左心室肥厚组(NLVH组),比较两组一般临床资料,并利用多因素Logistic回归模型分析AIP与LVH的相关性(分层分析)。结果左心室肥厚组的年龄、身高、体质量、身体质量指数(BMI)、血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖、AIP、AC、非高密度脂蛋白胆固醇(non-HDL-C)高于非左心室肥厚组,差异有统计学意义(P<0.05)。单因素Logistics回归分析显示,AIP、AC、non-HDL-C水平与LVH呈正相关(P<0.05);多因素Logistics回归分析显示,在调整性别、年龄、BMI、吸烟史、饮酒史等多项人口学指标及既往史指标后,AIP与LVH发病风险的相关性更强(O R=4.33,95%CI:1.76~10.64,P<0.01)。按性别、年龄、BMI、吸烟史、饮酒史、糖尿病史、高血脂、冠心病史、心肌梗死病史进行分层分析,AIP和LVH之间的相关性是稳定的,差异无统计学意义(P>0.05)。结论高血压患者AIP是LVH的独立危险因素,为高血压LVH的预防、诊断提供新的靶点。Objective To analyze the correlation between plasma atherogenic index(AIP)and left ventricular hypertrophy(LVH)in patients with primary hypertension.Methods This study is a retrospective analysis,the hypertensive patients from the Cardiovascular Department of the Second Affiliated Hospital of Baotou Medical College from January 2022 to December 2021.Based on the left ventricular mass index,patients were categorized into the LVH group and non-LVH group.The differences in general clinical data between the two groups were compared.A multiple logistic regression model was used to analyze the correlation between AIP and LVH(stratified analysis).Results In the LVH group,age,height,weight,BMI,TC,TG,LDL-C,fasting blood glucose,AIP,AC,and non-HDL-C were higher than in the non-LVH group,and the differences were significant(P<0.05).Univariate logistic regression analysis showed that AIP,AC,and non-HDL-C levels were positively correlated with LVH(P<0.05).Multivariate logistic regression analysis,adjusting for gender,age,BMI,smoking history,alcohol consumption history,and other demographic and past history indicators,showed a stronger correlation between AIP and the risk of LVH(OR=4.33,95%CI:1.76~10.64,P<o.01).Stratified analysis based on gender,age,BMI,smoking history,alcohol consumption history,diabetes history,hyperlipidemia,coronary heart disease history,and myocardial infarction history demonstrated a stable correlation between AIP and LVH(P>0.05).Conclusion Elevated AIP in hypertensive patients is an independent risk factor for LVH,providing a new target for the prevention and diagnosis of left ventricular hypertrophy in hypertension.

关 键 词：原发性高血压 血浆致动脉粥样硬化指数 左心室肥厚 

分 类 号：R544.1[医药卫生—心血管疾病]