免疫细胞亚群在顺铂肾毒性中的作用研究进展  

Research Progress on the Role of Immune Cell Subsets in Cisplatin Nephrotoxicity

作　　者：杨欣欣 吴珊珊 马俊杰 王若琦 朱海鑫 朱奕潜 林能明[1,2] 谭笔琴 YANG Xinxin;WU Shanshan;MA Junjie;WANG Ruoqi;ZHU Haixin;ZHU Yiqian;LIN Nengming;TAN Biqin(School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310006,China;Department of Clinical Pharmacology,Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,Affiliated Hangzhou First People's Hospital,School of Medicine,Westlake University,Hangzhou 310006,China)

机构地区：[1]浙江中医药大学药学院,杭州310006 [2]西湖大学医学院附属杭州市第一人民医院,浙江省临床肿瘤药理与毒理学研究重点实验室,临床药理研究室,杭州310006

出　　处：《中国现代应用药学》2024年第20期2884-2892,共9页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省临床肿瘤药理与毒理学研究重点实验室资助项目(2020E10021);浙江省高层次创新卫生人才培养计划项目(ZWB-2020-18);浙江省医学重点学科(省市共建);杭州市医学重点学科(HWF-2021-21-16)。

摘　　要：顺铂(cisplatin,DDP)作为临床最常用抗肿瘤药物之一,被广泛应用于肺癌、睾丸癌、卵巢癌等多种实体癌症,但同时因为其不良反应而受到诸多限制,如肾毒性、耳毒性、骨髓抑制等。其中,DDP的肾毒性是其最严重的不良反应之一,临床表现为血尿、血清肌酐升高、肾小管损伤等。目前的研究表明,炎症、细胞凋亡、自噬、氧化应激以及铁死亡等机制均在DDP肾毒性中发挥作用。本文重点从炎症反应中免疫细胞亚群入手,分别阐述了巨噬细胞、T细胞、树突状细胞以及其他免疫细胞在DDP肾毒性中的作用机制,并对近年来基于免疫治疗DDP肾毒性的进展进行综述,旨在为DDP肾毒性的预防和治疗药物研发提供理论依据。Cisplatin(DDP)is a commonly used anticancer drug in clinic,it is widely used in lung cancer,testicular cancer,ovarian cancer and other solid cancers.However,its side effects limit its clinical application,such as nephrotoxicity,ototoxicity,bone marrow suppression and so on.Among them,the nephrotoxicity of DDP is one of the most serious adverse reactions.The clinical manifestations of nephrotoxicity mainly include hematuria,elevated serum creatinine,renal tubular injury.Recent studies have shown that inflammation,apoptosis,autophagy,oxidative stress and ferroptosis all play an important role in the nephrotoxicity of DDP.This article focuses on the immune cells,and reviews the mechanism of macrophages,T cells,dendritic cells and other immune cells in the nephrotoxicity of DDP in recent years,the present text aims to provide a theoretical basis for the prevention and treatment of the nephrotoxicity of DDP.

关 键 词：顺铂肾毒性 炎症 巨噬细胞 T细胞 树突状细胞 

分 类 号：R967[医药卫生—药理学]