酒精代谢活力的动态变化和性别二态性  

Dynamic changes and sexual dimorphism of alcohol metabolic activity

作　　者：曹盈莹 郝佩佩 王佳宇 任毕达 张坤[1] 薛永志[1] CAO Yingying;HAO Peipei;WANG Jiayu;REN Bida;ZHANG Kun;XUE Yongzhi(School of Basic Medicine and Forensic Medicine,Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040,China;2020 Undergraduate Class,Baotou Medical College,Inner Mongolia University of Science and Technology)

机构地区：[1]内蒙古科技大学包头医学院基础医学与法医学院,内蒙古包头014040 [2]内蒙古科技大学包头医学院

出　　处：《包头医学院学报》2024年第11期1-4,共4页Journal of Baotou Medical College

基　　金：国家自然科学基金项目(81460567,82160709);内蒙古自然科学基金项目(2023MS08066);内蒙古自治区研究生教育教学改革项目(JGCG2022148);大学生创新创业项目(2023);花蕾计划(2023)。

摘　　要：目的:探究酒精多次摄入后代谢活力的动态变化,分析代谢酶代谢活力的诱导作用和性别差异。方法:采用呼气酒精检测仪器建立大鼠呼气末酒精检测方法并检测大鼠灌胃酒精后呼气酒精浓度,借此动态地测量大鼠摄入酒精后的血酒浓度经时变化,计算药代动力学参数,评价细胞色素P4502E1(cytochrome P4502E1,CYP2E1)代谢活力和大鼠性别差异。结果:随着酒精摄入次数的增加,CYP2E1代谢活力呈现诱导趋势(P<0.05);雌性大鼠酒精代谢活力强于雄性(P<0.05)。结论:酒精代谢和诱导作用具有性别二态性。Objective:To explore the dynamic changes of metabolic activity after multiple intakes of alcohol,and to analyze the induction and gender differences of metabolic enzyme activity.Methods:The end-expiratory alcohol detection method of rats was established by breath alcohol detectors,and the breath alcohol concentration of rats after intragastric administration of alcohol was detected.The time-varying changes of blood alcohol concentration of rats after alcohol intake were dynamically measured,and the pharmacokinetic parameters were calculated to evaluate cytochrome P4502E1(CYP2E1)metabolic activity and gender differences in rats.Results:With the increase of alcohol intake,the metabolic activity of CYP2E1 showed an induced trend(P<0.05).The activity of alcohol metabolism in female rats was stronger than that in male rats(P<0.05).Conclusion:Alcohol metabolism and induction have sexual dimorphism.

关 键 词：细胞色素P4502E1 性别二态性:酒精代谢 大鼠 呼气酒精检测仪 

分 类 号：R285.5[医药卫生—中药学]