基于R软件的某中医院治疗骨折延迟愈合中药方剂数据挖掘  

Data Mining of Traditional Chinese Medicine Prescriptions for Treating Delayed Fracture Healing in A Certain Traditional Chinese Medicine Hospital Based on R Software

作　　者：熊伟[1] 程凌 李文文 叶晓波 韦玲芝 XIONG Wei;CHENG Ling;LI Wenwen;YE Xiaobo;WEI Lingzhi(Rehabilitation Medicine Department,Hongdu Traditional Chinese Medicine Hospital,Jiangxi Nanchang 330008,China;Quality Control Office of Hongdu Traditional Chinese Medicine Hospital,Jiangxi Nanchang 330008,China)

机构地区：[1]江西省南昌市洪都中医院康复医学科,江西南昌330008 [2]江西省南昌市洪都中医院质控办,江西南昌330008

出　　处：《中国医药导刊》2024年第9期909-916,共8页Chinese Journal of Medicinal Guide

基　　金：江西省中医药管理局科技计划(2022B017);江西省中医药中青年骨干人才(第四批)培养计划(赣中医药科教字〔2022〕7号文);南昌市市级重点专科计划(洪卫体改字〔2021〕7号)。

摘　　要：目的:探讨我院应用中药方剂治疗骨折延迟愈合的效果,并总结其治疗规律,为临床提供新的中医诊疗思路。方法:采用回顾性研究方法,收集我院HIS系统中符合纳入标准的骨折延迟愈合患者的临床资料。使用R软件进行数据分析,包括频次分析、关联规则、phi相关性分析和聚类分析,以探索中药方剂的组方模式及其中的诊疗思路。结果:共纳入215例病例,包括药物179种,药物类型42种,药物功效308种,药物主治病症566种,四气以温、平为主,五味以甘、苦、辛为主,归经以肝、肾、肺为主,强关联对药21个、角药262个,药物共现网络有73个节点、806条边。其中“骨碎补、杜仲、自然铜、淫羊藿、狗脊、土鳖虫、龙骨、续断、合欢皮、黄芪、红花”药物之间phi相关性最高;可能的新方剂组合4个,包括“狗脊、龙骨、自然铜、杜仲、黄芪、淫羊藿、土鳖虫”“合欢皮、骨碎补、牛膝、续断、当归、川芎、红花”“青风藤、蜈蚣、地龙、桂枝、粉葛”“麦芽、山楂、薏苡仁、北沙参、白术、远志、苍术、酸枣仁、茯苓、甘草、珍珠母”。结论:我院治疗骨折延迟愈合采用的中药方剂为补益肝肾、续筋接骨为主的药物,形成了治疗骨折延迟愈合的新方剂组合,为未来的中医药治疗策略提供了创新思路。Objective:To investigate the efficacy of traditional Chinese medicine(TCM)prescriptions in the treatment of delayed frac-ture healing at our hospitial and to summarize the treatment patterns,providing new TCM diagnostic and treatment approaches for clinical practice.Methods:A retrospective case study method was used,to collect the clinical data of patients with delayed fracture healing were collected who met the inclusion criteria from the HIS system of our hospital.Data analysis was performed using R software,including fre-quency analysis,association rules,phi correlation analysis,and cluster analysis,to explore the prescription patterns and treatment ideas of TCM.Results:A total of 215 cases were included,with 179 types of drugs,42 types of drug categories,308 types of drug effects,and 566 types of diseases treated.The four properties(Qi)were mainly warm and neutral,the five flavors(Wei)were mainly sweet,bitter,and pungent,and the channels entered were mainly liver,kidney,and lung.There were 21 strong associated drug pairs,262 core drugs,and 73 nodes with 806 edges in the drug co-occurrence network.Among these,"Drynaria,Eucommia,Pyrite,Epimedium,Rhi-zoma Cibotii,Ground Beetle,Os Draconis,Radix Dipsaci,Cortex Albizziae,Radix Astragali,Safflower"had the highest phi correla-tion.Four possible new prescription combinations were identified,including"Rhizoma Cibotii,Os Draconis,Pyrite,Eucommia,Radix Astragali,Epimedium,Ground Beethe""Cortex Albizziae,Drynaria,Radix Achyranthis Bidentatae,Radix Dipsaci,Radix Angelicae Sinensis,Rhizoma Chuanxiong,Safflower""Caulis Sinomenii,Centipede,Earthworm,Cassia Twig,Puerariae Thomsonii Radix"and"Malt,hawthorn frvie,Coix Seed,Coastal Glehnia Root,Rhizoma Atractylodis Macrocephalae,Polygala root,Rhizoma Atractylo-dis,Spine Date Seed,Poria,Licorice,Nacre".Conclusion:The TCM prescriptions used at our hospital for the treatment of delayed fracture healing primarily focus on tonifying the liver and kidney and promoting tendon and bone healing.This study has formulted new prescription c

关 键 词：骨折延迟愈合 中医药治疗 数据挖掘 中药方剂 R软件分析 

分 类 号：R245[医药卫生—针灸推拿学] R683[医药卫生—中医临床基础]