高龄(≥40岁)男性的多精受精指标可能与年轻男性并无显著差异:一项倾向性评分匹配研究  

No difference in polyspermia index between older men(≥40 years)and younger men:a propensity score matching study

作　　者：李光耀 周桥 季慧[1] 季娟[1] 凌秀凤[1] LI Guangyao;ZHOU Qiao;JI Hui;JI Juan;LING Xiufeng(Center of Reproduction Medicine,Nanjing Maternal and Child Healthcare Hospital Affiliated to Nanjing Medical University,Nanjing Maternity and Child Healthcare Hospital,Nanjing 210004,China)

机构地区：[1]南京医科大学附属妇产医院,南京市妇幼保健院生殖医学中心,江苏南京210004

出　　处：《现代泌尿外科杂志》2024年第11期951-955,共5页Journal of Modern Urology

基　　金：国家自然科学基金资助项目(No.81871210);南京市卫生科技发展专项资金项目(No.YKK21158)。

摘　　要：目的探讨男性高龄因素对多精受精发生率的影响。方法本研究纳入了南京医科大学附属妇产医院生殖医学中心2016年1月—2022年9月的4210个体外受精(IVF)周期数据,按照男方的年龄进行分组,<40岁的年轻组患者4053例,≥40岁的高龄组患者157例。经过倾向性评分匹配后筛选出高龄组152例患者,年轻组421例患者。比较两组患者的基线资料以及多精受精发生率的差异。结果经过倾向性评分匹配后,两组患者在女方年龄、不育类型、不育年限、不孕因素、女方身体质量指数(BMI)、男方BMI、精液量、精液pH值、精子浓度、精子活力、前向运动精子百分比、正常精子形态百分比、受精卵数、MⅡ卵子数方面的差异均无统计学意义(P>0.05);分析结果表明573个新鲜IVF周期中出现3原核(PN)周期的几率为35.5%,多PN受精卵发生率为6.5%。高龄组的多精受精卵数、可移植胚胎数、优质胚胎数、形成囊胚数与年轻组比较未见显著差异(P>0.05)。结论与年轻男性相比,男性高龄(≥40岁)对卵子多精受精发生率并无明显影响。Objective To investigate the effects of advanced male age on the incidence of polyspermy fertilization.Methods The study involved data of 4210 in vitro fertilization(IVF)cycles treated in our center during Jan.2016 and Sep.2022,including 4053 patients younger than 40 years and 157 patients above 40 years.After propensity score matching,152 patients in the advance group and 421 in the young group were recruited.The baseline data and the difference in polyspermy fertilization rate were compared between the two groups.Results After propensity score matching,there were no significant differences between the two groups in terms of female age,infertility type,infertility years,infertility factors,female body mass index(BMI),male BMI,semen volume,semen pH value,sperm concentration,sperm motility,progressive motility rate,percentage of normal sperm morphology,number of fertilized eggs and number of MⅡeggs(P>0.05).Among the 573 fresh IVF cycles,the rate of 3 PN cycles was 35.5%,and the incidence of polyspermy fertilization was 6.5%.There were no significant differences in the number of polyspermy fertilized eggs,transferable embryos,high-quality embryos,and blastocysts between the two groups.Conclusion Advanced male age has no significant effect on the incidence of polyspermy fertilization.

关 键 词：体外受精 多原核 倾向性评分匹配 可移植胚胎 男性高龄 

分 类 号：Q492.6[生物学—生理学]