泉州地区献血人群ABO、Rh血型分布特点分析  

Distribution of ABO and Rh blood group among blood donors in Quanzhou

作　　者：侯志婷 林毅胜 丁培燕 陈吓燕 黄小静 章永明 HOU Zhiting;LIN Yisheng;DING Peiyan;CHEN Xiayan;HUANG Xiaojing;ZHANG Yongming(Quanzhou Central Blood Station,Quanzhou,Fujian 362000,China)

机构地区：[1]福建省泉州市中心血站,泉州362000

出　　处：《福建医药杂志》2024年第6期14-17,共4页Fujian Medical Journal

基　　金：泉州市科技计划项目(2022NS038)。

摘　　要：目的探讨泉州地区献血人群ABO和Rh血型分布特点,丰富稀有表型资料库,以期指导采供血计划和无偿献血者招募策略的制订,保障泉州地区的临床用血。方法收集2018—2022年泉州市190195名献血者数据,分析其ABO和RhD血型分布特点,进行ABO血型Hardy-Weinberg吻合度检验,并对2022年8月至2024年4月本站RhD阴性标本进行RhC、c、E、e抗原分型检测,建立稀有表型资料库。结果泉州地区献血人群ABO表现型O>A>B>AB,基因频率r>p>q,期望值与观察值差异有统计学意义,不符合Hardy-Weinberg遗传规律。汉族RhD阴性献血者占比0.44%,271名RhD阴性献血者中,共检出6种表现型:ccdee>Ccdee>CCdee>ccdEe>CcdEe>--dee;未检出CcdEE、ccdEE、CCdEE、CCdEe,2例未检出C(c)抗原,RhC、c、E、e抗原频率由高到低均为e>c>C>E。结论血型遗传规律不能真实反映献血人群的血型分布,根据研究所得的献血人群ABO和Rh血型分布特点可用来指导制订采供血计划和精准的无偿献血者招募策略,保障本地区的血液供应。Objective Determining the distribution of ABO and Rh phenotypes among blood donors in Quanzhou and enriching the rare phenotype database will allow us to ensure better management of blood stocks and good recruitment strategies for supplying Quanzhou with blood products.Methods The data of 190195 blood donors in Quanzhou from 2018 to 2022 were collected to analyze the ABO and RhD blood group distribution characteristics,and the ABO blood group were performed Hardy-Weinberg equilibrium test;RhC,c,E and e antigen typing detections were performed on RhD-negative individuals from August 2022 to April 2024 to establish a rare phenotype database.Results O>A>B>AB and r>p>q in our blood donors were noticed.The differences between expected frequency and observed frequency were statistically significant which didn't accord with Hardy-Weinberg equilibrium rules.The frequency of RhD-Negative in Han nationality blood donors was 0.44%.We found 6 phenotypes among 271 RhD negative blood donors:ccdee>Ccdee>CCdee>ccdEe>CcdEe>--dee;no CcdEE,ccdEE,CCdEE,CCdEe were detected,and no C(c)antigen was detected in 2 cases.The frequency of RhC,c,E,e antigens was e>c>C>E respectively.Conclusion The genetic rules of blood group can not truly reflect the blood group distribution of blood donors.The ABO and Rh blood group distribution characteristics of blood donors obtained in this study can be used to guide the development of blood procurement plans and accurate recruitment strategies for blood donors,so as to ensure the blood supply in our region.

关 键 词：ABO血型 RH血型 血型分布 基因频率 泉州 

分 类 号：R457[医药卫生—治疗学]