黄葵胶囊联合氢氯噻嗪片治疗慢性肾小球肾炎的效果及对患者24 h尿蛋白定量、氧化应激的影响  

Effect of Huangkui Capsule Combined with Hydrochlorothiazide Tablet in the Treatment of Chronic Glomerulonephritis and Its Influence on 24 h Urinary Protein Quantification and Oxidative Stress

作　　者：杨传源 YANG Chuanyuan(Department of Internal Medicine,Lanling People's Hospital,Linyi 276000,China)

机构地区：[1]兰陵县人民医院内科,山东临沂276000

出　　处：《反射疗法与康复医学》2024年第17期25-28,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探究氢氯噻嗪片、黄葵胶囊联合治疗慢性肾小球肾炎的效果及对患者24 h尿蛋白定量、氧化应激的影响。方法选取兰陵县人民医院2021年4月—2023年6月收治的84例慢性肾小球肾炎患者为研究对象,使用随机数字表法将其分为对照组与观察组,各42例。对照组接受氢氯噻嗪片治疗,观察组接受黄葵胶囊、氢氯噻嗪片联合治疗,两组治疗时间均为2个月。比较两组的临床疗效、肾功能指标、24 h尿蛋白定量、氧化应激指标及不良反应发生情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组肾功能及氧化应激各项指标水平比较,组间差异无统计学意义(P>0.05);治疗后,观察组血肌酐、尿素氮及血清丙二醛水平均低于对照组,血清超氧化物歧化酶水平高于对照组,组间差异有统计学意义(P<0.05);治疗前,两组患者24 h尿蛋白定量比较,差异无统计学意义(P>0.05);治疗1、2个月后,观察组24 h尿蛋白定量水平均低于对照组,组间差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论对慢性肾小球肾炎联用黄葵胶囊、氢氯噻嗪片治疗的效果显著,可促使患者的肾功能改善,调节24 h尿蛋白定量,减轻氧化应激反应,且安全性良好。Objective To explore the effect of hydrochlorothiazide tablets combined with Huangkui capsule in the treatment of chronic glomerulonephritis and its influence on 24 h urinary protein quantification and oxidative stress.Methods A total of 84 patients with chronic glomerulonephritis admitted to Lanling People's Hospital from April 2021 to June 2023 were selected as the research objects.They were divided into a control group and an observation group by the random number table method,with 42 cases in each group.The control group was treated with hydrochlorothiazide tablets,and the observation group was treated with Huangkui capsule and hydrochlorothiazide tablets,the treatment time for both group was 2 months.The clinical efficacy,renal function indexes,24 h urinary protein quantification,oxidative stress indexes and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Before treatment,there was no significant difference in the levels of renal function and oxidative stress between the two groups(P>0.05);after treatment,the levels of serum creatinine,blood urea nitrogen and serum malondialdehyde in the observation group were lower than those in the control group,and the level of serum superoxide dismutase was higher than that in the control group,and the differences between the two groups were statistically significant(P<0.05);before treatment,there was no statistically significant difference in 24 h urinary protein between the two groups(P>0.05);after 1 and 2 months of treatment,the 24-hour urinary protein quantitative level of the observation group was lower than that of the control group,and the differences between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Huangkui capsule combined with hydrochlorothiazide tablets in the treatment of chroni

关 键 词：慢性肾小球肾炎 黄葵胶囊 氢氯噻嗪 临床疗效 24 h尿蛋白定量 氧化应激 

分 类 号：R692[医药卫生—泌尿科学]