肺部感染患者多重耐药菌的耐药性研讨  

Study on drug resistance of multi-drug resistant bacteria in patients with pulmonary infection

作　　者：崔国华 CUI Guo-hua(Department of Internal Medicine and Critical Care Medicine,Qidong Second People's Hospital,Qidong 226241,China)

机构地区：[1]启东市第二人民医院内科重症医学科,226241

出　　处：《中国实用医药》2024年第21期71-74,共4页China Practical Medicine

摘　　要：目的 探究肺部感染患者多重耐药菌(MDR)的耐药性。方法 选取50例肺部感染患者,取患者痰液样本进行致病菌培养及药敏试验。分析肺部感染多重耐药菌构成情况、革兰阴性菌的耐药情况及革兰阳性菌的耐药情况。结果 50例肺部感染患者的痰液样本中总共分离出255株病原菌,其中95株(37.3%)鉴定为多重耐药菌。多重耐药菌中,革兰阴性菌为75株(78.9%),革兰阳性细菌20株(21.1%)。19株铜绿假单胞菌对哌拉西林、头孢他啶、头孢吡肟、氨曲南、环丙沙星的耐药率>63%;16株肺炎克雷伯菌对氨苄西林/舒巴坦、头孢唑林、头孢他啶、头孢呋辛、头孢曲松的耐药率>56%;14株鲍氏不动杆菌对氨苄西林、氨苄西林/舒巴坦、头孢吡肟、阿米卡星的耐药率≥50%;11株大肠埃希菌对氨苄西林/舒巴坦、头孢唑林、头孢他啶、头孢呋辛、头孢曲松、氨曲南、左氧氟沙星、复方新诺明的耐药率>54%;7株嗜麦芽窄食单胞菌对头孢唑林、左氧氟沙星的耐药率>57%。7株金黄色葡萄球菌对头孢西丁、青霉素、红霉素、克林霉素、庆大霉素的耐药率>57.0%;4株表皮葡萄球菌对头孢西丁、青霉素、红霉素、克林霉素、庆大霉素、复方新诺明的耐药率≥75%;4株肺炎链球菌对红霉素、克林霉素的耐药率均为100%。结论 肺部感染患者痰液样本中出现多重耐药菌,分析不同细菌对不同抗生素产生不同的耐药性,可为随后肺部感染的控制提供重要参考依据。Objective To investigate the drug resistance of multi-drug resistant bacteria(MDR)in patients with pulmonary infection.Methods 50 patients with pulmonary infection were selected to undergo pathogen culture and drug susceptibility test.The composition of multi-drug resistant bacteria,drug resistance of gram-negative bacteria and drug resistance of gram-positive bacteria in pulmonary infection were analyzed.Results A total of 255 stains of pathogenic bacteria were isolated from the sputum samples of 50 patients with pulmonary infection,of which 95 strains(37.3%)were identified as multi-drug resistant bacteria.There were 75 strains(78.9%)of Gram-negative bacteria and 20 strains(21.1%)of Gram-positive bacteria in multi-drug resistant bacteria.The drug resistance rate of 19 strains of Pseudomonas aeruginosa to piperacillin,ceftazidme,cefepime,aztreonam and ciprofloxacin was>63%.The drug resistance rate of 16 strains of Klebsiella pneumoniae to ampicillin/sulbactam,cefazolin,ceftazidme,cefuroxime and ceftriaxone was more than 56%.The drug resistance rate of 14 strains of Acinetobacter baui to ampicillin,ampicillin/sulbactam,cefepime and amikacin was≥50%.The drug resistance rate of 11 E.coli strains to ampicillin/sulbactam,cefazolin,ceftazidme,cefuroxime,ceftriaxone,aztreonam,levofloxacin and cotrimoxazole was>54%.The drug resistance rate of 7 strains of stenotrophomonas maltophilia to cefazolin and levofloxacin was>57%.The drug resistance rate of 7 strains of Staphylococcus aureus to cefoxitin,penicillin,erythromycin,clindamycin,and gentamicin was>57.0%.The drug resistance rate of 4 strains of Staphylococcus epidermidis to cefoxitin,penicillin,erythromycin,clindamycin,gentamicin and cotrimoxazole was≥75%.The drug resistance rate of 4 strains of Streptococcus pneumoniae to erythromycin and clindamycin was 100%.Conclusion Multi-drug resistant bacteria has been found in sputum samples of patients with pulmonary infection,and analysis of the resistance of different bacteria to different antibiotics can provide an impor

关 键 词：肺部感染 多重耐药菌 耐药性 革兰阴性菌 革兰阳性菌 药敏试验 

分 类 号：R563.1[医药卫生—呼吸系统] R446.5[医药卫生—内科学]