拉贝洛尔与拜新同联合治疗对早发型重度子痫前期患者血压及妊娠结局的影响  

Effect of Combined Treatment with Labelol and Benzitone on Blood Pressure and Pregnancy Outcomes in Patients with Early-Onset Severe Preeclampsia

作　　者：吴洪枝 WU Hongzhi(Department of Obstetrics and Gynecology,the Second People's Hospital of Binzhou City,Binzhou 256800,China)

机构地区：[1]滨州市第二人民医院产科,山东滨州256800

出　　处：《反射疗法与康复医学》2024年第15期52-55,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨拉贝洛尔与拜新同联合治疗对早发型重度子痫前期患者的影响。方法选择滨州市第二人民医院2021年3月—2023年3月收治的82例早发型重度子痫前期患者为研究对象,采用随机数字表法将其分为对照组和观察组,每组41例。对照组采用拜新同治疗,观察组在对照组基础上采用拉贝洛尔治疗,两组均持续治疗到终止妊娠前1 d。对比两组的临床疗效、血压、24 h蛋白尿水平、凝血功能、不良妊娠结局发生情况及不良反应发生情况。结果观察组治疗总有效率为95.12%,高于对照组的78.05%,差异有统计学意义(P<0.05)。治疗后,观察组收缩压、舒张压、24 h蛋白尿水平均低于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组活化部分凝血活酶时间、凝血酶原时间、血浆凝血酶时间均长于对照组,纤维蛋白原水平低于对照组,组间差异有统计学意义(P<0.05)。观察组不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论早发型重度子痫前期患者采用拉贝洛尔联合拜新同治疗的临床效果确切,能够有效调节血压及24 h蛋白尿水平,改善凝血功能、妊娠结局,且不增加不良反应发生率。Objective To investigate the effect of the combination therapy of Labelol and Benzitone on patients with early-onset severe preeclampsia.Methods Eighty-two patients with early-onset severe preeclampsia admitted to the Second People's Hospital of Binzhou City from March 2021 to March 2023 were selected as the study subjects.They were randomly divided into a control group and an observation group using a random number table method,with 41 cases in each group.The control group received treatment with Benzitone,while the observation group received treatment with Labelol on this basis.Both groups continued treatment until 1 day before termination of pregnancy.The clinical efficacy,blood pressure,24-hour proteinuria level,coagulation function,adverse pregnancy outcomes and adverse reactions between the two groups were compared.Results The total effective rate of the observation group was 95.12%,which was higher than the control group's 78.05%,and the difference was statistically significant(P<0.05).After treatment,the systolic blood pressure,diastolic blood pressure,and 24-hour proteinuria levelin the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the activated partial thromboplastin time,prothrombin time,and plasma thrombin timein the observation group were all longer than those in the control group,the level of fibrinogenwas lower than that in the control group,and the differences between the groups were statistically significant(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In patients with early-onset severe preeclampsia,the use of Labelol combined with Benzitone has a definite clinical effect,can effectively regulate patient blood pressure and 24-hour pr

关 键 词：早发型重度子痫前期 拉贝洛尔 拜新同 血压 妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学]