氨溴特罗辅助头孢克洛治疗小儿急性支气管炎的效果观察  

Effect of Ambroterol Assisted Cefaclor in the Treatment of Acute Bronchitis in Children

作　　者：邱洁 QIU Jie(Department of Pediatrics,Lanshan District People’s Hospital of Rizhao,Rizhao 276800,China)

机构地区：[1]日照市岚山区人民医院儿科,山东日照276800

出　　处：《反射疗法与康复医学》2024年第15期63-65,85,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨氨溴特罗辅助头孢克洛治疗小儿急性支气管炎的具体效果。方法选取我院2021年1月—2024年1月收治的74例急性支气管炎患儿为研究对象,以随机数字表法将其分为对照组和观察组,每组37例。对照组采取头孢克洛治疗,观察组在此基础上采取氨溴特罗治疗。治疗1周后,对比两组的临床疗效、血清炎症因子水平、血气指标及不良反应发生情况。结果观察组治疗总有效率为97.30%,高于对照组的78.38%,差异有统计学意义(P<0.05)。治疗后,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-1β(IL-1β)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血氧饱和度(SaO_(2))、动脉氧分压(PaO_(2))水平均高于治疗前,动脉二氧化碳分压(PaCO_(2))水平均低于治疗前,且观察组SaO_(2)、PaO_(2)水平均高于对照组,PaCO_(2)水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论氨溴特罗辅助头孢克洛治疗小儿急性支气管炎有利于提升临床疗效,对炎症症状及血气指标的改善效果良好,且不良反应较少。Objective To explore the specific effect of ambroterol assisted cefaclor in the treatment of acute bronchitis in children.Methods Seventy-four children with acute bronchitis admitted to our hospital from January 2021 to January 2024 were selected as the research subjects.They were randomly divided into a control group and an observation group using a random number table method on this basis,with 37 cases in each group.The control group was treated with cefaclor,and the observation group was treated with ambroterol on this basis.After 1 week of treatment,the clinical efficacy,serum inflammatory factor levels,blood gas indexes and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.30%,higher than 78.38%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-1β(IL-1β)in both groups were lower than before treatment,and the observation group were lower than the control group,the difference were statistically significant(P<0.05).After treatment,the levels of blood oxygen saturation(SaO_(2))and arterial partial pressure of oxygen(PaO_(2))in both groups were higher than before treatment,and the levels of arterial partial pressure of carbon dioxide(PaCO_(2))were lower than before treatment,in addition,the levels of SaO_(2)and PaO_(2)in the observation group were higher than those in the control group,and the level of PaCO_(2)was lower than that in the control group,the difference were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ambroterol assisted cefaclor in the treatment of acute bronchitis in children is beneficial to improve clinical efficacy,and has a good effect on inflammatory symptoms and blood gas indexes,with fewer adverse reactions.

关 键 词：急性支气管炎 氨溴特罗 头孢克洛 临床疗效 炎症因子 

分 类 号：R725.6[医药卫生—儿科]