乙酰谷酰胺联合纳洛酮在急性重度酒精中毒患者急诊治疗中的应用观察  

Application of Acetoglutamide Combined with Naloxone in the Emergency Treatment of Patients with Acute Severe Alcoholism

作　　者：路文婷 LU Wenting(Department of Emergency Internal Medicine,Shandong Province Jining City Yanzhou District People's Hospital,Jining 272100,China)

机构地区：[1]山东省济宁市兖州区人民医院急诊内科,山东济宁272100

出　　处：《反射疗法与康复医学》2024年第10期148-151,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探究乙酰谷酰胺与纳络酮联合应用在急性重度酒精中毒患者急诊治疗中的应用效果。方法选取2020年10月—2023年10月山东省济宁市兖州区人民医院收治的50例急性重度酒精中毒患者为研究对象,按随机数字表法将其分为对照组和观察组,各25例,对照组采用纳洛酮治疗,观察组在对照组的基础上联合乙酰谷酰胺治疗,比较两组的临床疗效、恢复时间、氧化应激指标及不良反应发生情况。结果观察组治疗总有效率为92.00%,高于对照组的68.00%,差异有统计学意义(P<0.05)。观察组清醒、体温恢复及生命体征恢复时间均短于对照组,组间差异有统计学意义(P<0.05)。治疗第3天,观察组超氧化物歧化酶水平高于对照组,血清丙二醛水平低于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论纳络酮与乙酰谷酰胺注射液联合治疗可促进急性重度酒精中毒患者加速清醒,加快酒后症状消退,调节氧化应激指标,效果显著,且毒副作用较轻。Objective To explore the application effect of acetylglutamine combined with naloxone in the emergency treatment of patients with acute severe alcoholism.Methods A total of 50 patients with acute severe alcoholism admitted to Shandong Province Jining City Yanzhou District People's Hospital from October 2020 to October 2023 were selected as the research objects,and they were divided into a control group and an observation group according to the random number table method,with 25 cases in each group.The control group was treated with naloxone,and the observation group was treated with acetylglutamine on the basis of the control group.The clinical efficacy,recovery time,oxidative stress indexes and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 92.00%,which was higher than 68.00%of the control group,and the difference was statistically significant(P<0.05).The waking,body temperature recovery and vital signs recovery time of the observation group were shorter than those of the control group,and the differences between the two groups were statistically significant(P<0.05).On the third day of treatment,the superoxide dismutase level of the observation group was higher than that of the control group,and the serum malondialdehyde level was lower than that of the control group,and the differences between the two groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion Naloxone combined with acetylglutamine injection can accelerate the recovery of patients with acute severe alcoholism,accelerate the disappearance of symptoms after drinking,regulate oxidative stress indicators,and the effect is significant,and the toxic side effects are mild.

关 键 词：急性重度酒精中毒 乙酰谷酰胺 纳洛酮 临床疗效 氧化应激指标 

分 类 号：R595.6[医药卫生—内科学]