莫西沙星联合亚胺培南西司他丁钠对老年重症肺炎患者的影响  

Effect of Moxifloxacin Combined with Imipenem and Cilastatin Sodium on Elderly Patients with Severe Pneumonia

作　　者：黄雪 HUANG Xue(Department of Respiratory and Critical Care Medicine,Guiyang Public Health Clinical Center,Guiyang 550001,China)

机构地区：[1]贵阳市公共卫生救治中心呼吸与重症医学科,贵州贵阳550001

出　　处：《反射疗法与康复医学》2024年第11期171-174,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨莫西沙星联合亚胺培南西司他丁钠对老年重症肺炎患者的肺功能、炎症因子水平及临床症状消失时间的影响。方法回顾性分析2022年1月—2023年8月贵阳市公共卫生救治中心收治的120例重症肺炎患者的临床资料。按治疗方法的不同将其分为对照组与观察组,各60例。对照组采用亚胺培南西司他丁钠治疗,观察组采用莫西沙星联合亚胺培南西司他丁钠治疗,两组均连续治疗10 d。比较两组患者的临床症状消失时间、肺功能及炎症因子水平。结果观察组高热消失时间为(4.68±0.92)d,肺部啰音消失时间为(5.36±0.73)d,咳嗽消失时间为(5.41±0.86)d,呼吸困难消失时间为(4.89±0.77)d,均短于对照组的(7.24±1.06)d、(8.11±1.46)d、(7.94±1.33)d、(6.83±1.63)d,组间差异有统计学意义(P<0.05)。治疗后,观察组第1秒用力呼气容积为(2.85±0.22)L、用力肺活量为(3.05±0.33)L,均大于对照组的(2.39±0.27)L、(2.52±0.28)L,呼气流量峰值为(2.98±0.36)L/s,高于对照组的(2.55±0.28)L/s,组间差异有统计学意义(P<0.05);观察组超敏C反应蛋白为(6.53±2.14)mg/L,血沉为(21.32±6.93)mm/H,白细胞介素-6为(11.71±3.36)pg/mL,肿瘤坏死因子-α为(18.85±3.16)pg/mL,均低于对照组的(8.43±1.13)mg/L,(23.45±6.43)mm/H,(14.70±4.48)pg/mL,(23.00±5.20)pg/mL,组间差异有统计学意义(P<0.05)。结论与亚胺培南西司他丁钠单药治疗相比,联合莫西沙星治疗老年重症肺炎可更有效降低炎症因子水平,缓解临床症状,提高肺功能。Objective To investigate the effects of moxifloxacin combined with imipenem and cilastatin sodium on lung function,inflammatory factor levels and clinical symptom resolution time in elderly patients with severe pneumonia.Methods The clinical data of 120 patients with severe pneumonia admitted to Guiyang Public Health Clinical Center from January 2022 to August 2023 were retrospectively analyzed.According to the different treatment methods,they were divided into a control group and an observation group,with 60 cases in each group.The control group was treated with imipenem and cilastatin sodium,and the observation group was treated with moxifloxacin combined with imipenem and cilastatin sodium,both groups were treated continuously for 10 days.The clinical symptom resolution time,lung function and inflammatory factor levels were compared between the two groups.Results In the observation group,the time for high fever to disapppearance was(4.68±0.92)d,the time for pulmonary rale to disappear was(5.36±0.73)d,the time for cough to disappear was(5.41±0.86)d,and the time for dyspnea to disappear was(4.89±0.77)d,which were shorter than(7.24±1.06)d,(8.11±1.46)d,(7.94±1.33)d and(6.83±1.63)d in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the Forced Expiratory Volume for one second and forced vital capacity of the observation group were(2.85±0.22)L and(3.05±0.33)L,which were higher than(2.39±0.27)L and(2.52±0.28)L of the control group,and the peak expiratory flow was(2.98±0.36)L/s,which was higher than(2.55±0.28)L/s of the control group,and the differences between the groups were statistically significant(P<0.05);in the observation group,hypersensitive C-reactive protein was(6.53±2.14)mg/L,erythrocyte sedimentation rate(21.32±6.93)mm/H,interleukin-6 was(11.71±3.36)pg/mL,and tumor necrosis factor-αwas(18.85±3.16)pg/mL,which were lower than(8.43±1.13)mg/L,(23.45±6.43)mm/H,(14.70±4.48)pg/mL,(23.00±5.20)pg/mL of the control group,and the di

关 键 词：重症肺炎 莫西沙星 亚胺培南西司他丁钠 肺功能 炎症反应 

分 类 号：R563.1[医药卫生—呼吸系统]