水合氯醛应用于儿童ABR检测的安全性和有效性研究  

Safety and Effectiveness of Chloral Hydrate for Auditory Brainstem Response Tests in Children

作　　者：张湘玲 姚心怡 刘敏[1] 金悠悠 孟照莉[1] 刘昊天 郑芸[1] Zhang Xiangling;Yao Xinyi;Liu Min;Jin Youyou;Meng Zhaoli;Liu Haotian;Zheng Yun(Department of Otolaryngology-Head&Neck Surgery,West China Hospital,Sichuan University,Chengdu,610041,China)

机构地区：[1]四川大学华西医院耳鼻咽喉-头颈外科,成都610041

出　　处：《听力学及言语疾病杂志》2024年第6期524-527,共4页Journal of Audiology and Speech Pathology

基　　金：四川大学华西医院临床研究基金(2023HXFH018)。

摘　　要：目的分析水合氯醛应用于儿童听性脑干反应(ABR)检测的安全性和有效性。方法选取2015年12月至2022年3月在四川大学华西医院接受水合氯醛镇静(剂量30 mg/kg)进行ABR检查、年龄小于12岁的患儿5513例次(≤0.5岁2509例次、0.5~3岁2548例次、3~12岁546例次)为研究对象。回顾性分析镇静失败患者喂服方式(混合或直接喂服)、睡眠剥夺(是或否)、镇静失败表现(如无法入睡、镇静不足、浅睡眠状态)、不良事件(呕吐、烦躁等)等资料。计算总镇静失败率、不同年龄组镇静失败率及不良事件发生率。结果5513例次中镇静失败199例次(3.61%),上述不同年龄组镇静失败率分别为3.03%、4.31%、3.11%。199例次中,81.91%例次表现为镇静不足。不良事件发生率为10.55%,其中呕吐最常见。结论本研究对儿童ABR检测时镇静失败率及不良事件发生率相对既往国内外研究较低,可认为水合氯醛在此剂量安全有效。Objective To study the safety and effectiveness of chloral hydrate in children undergoing ABR tests.Methods From December 2015 to March 2022,5513 children under the age of 12 were selected for ABR examination in West China Hospital of Sichuan University,who received chloral hydrate sedation(dose of 30 mg/kg).Data on administration method(mixed or direct),sleep deprivation(yes or no),failure performance(such asfailure to sleep,insufficient sedation,superficial sleep),adverse events(vomiting,irritability,etc.)were retrospectively analyzed.Total sedation failure rate,sedation failure rates in different age groups(≤0.5 years,0.5~3 years,3~12 years)and adverse event rate were calculated.Results Among the 5513 ABR tests,199(3.61%)failed sedation.The sedation failure rates in different age groups(≤0.5 years,0.5~3 years,3~12 years)were 3.03%,4.31%and 3.11%,respectively.In the sedation failure tests,insufficient sedation was found in 81.91%of the tests.The incidence of adverse events was 10.55%,with most commonly vomiting.Conclusion The sedation failure rate and the incidence of adverse events of chloral hydrate at 30 mg/kg were relatively low,thus chloral hydrate can be considered safe and effective at this dose.

关 键 词：水合氯醛 听性脑干反应 镇静失败 

分 类 号：R764.04[医药卫生—耳鼻咽喉科]