异基因造血干细胞移植后合并重症肌无力2例报告并文献复习  

Myasthenia gravis after allogeneic hematopoietic stem cell transplantation:Two case reports and literature review

作　　者：石亚军 汉英 张晓菲 葸瑞 白海 吴涛 Shi Yajun;Han Ying;Zhang Xiaofei;Xi Rui;Bai Hai;Wu Tao(Department of Hematology,the 94th Hospital of Joint Logistics Support Force of Chinese People's Liberation Amy,Lanzhou 730050,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院血液科,兰州730050

出　　处：《中华血液学杂志》2024年第10期956-959,共4页Chinese Journal of Hematology

基　　金：甘肃省青年科技基金项目(23JRRA321);兰州市科技发展计划项目(2023-ZD-176);甘肃省创新基地和人才计划(21JR7RA015);甘肃省重点研发计划(22YF7FA106);联勤保障部队第九四〇医院血液病医学研究中心项目(2021yxky078);联勤保障部队第九四〇医院高层次人才工程项目(2024-G3-11)。

摘　　要：异基因造血干细胞移植后合并重症肌无力(MG)发病急,易快速进展,严重威胁移植后患者的生存。本文报道2例急性髓系白血病患者,行异基因造血干细胞移植后首发症状为气短,逐渐出现抬颈无力、呼吸困难,经乙酰胆碱受体抗体、新斯的明试验等检测,最终均诊断为MG。予溴吡斯的明、糖皮质激素或利妥昔单抗等治疗后病情均好转。The onset of myasthenia gravis(MG)after allogeneic hematopoietic stem cell transplantation(allo-HSCT)seriously threatens the survival of patients,since it is acute,and is prone to rapid progression.Two patients with acute myeloid leukemia(AML),who had undergone allo-HSCT developed shortness of breath,and gradually developed cervical weakness and dyspnea.The acetylcholine receptor(AChR)antibody and neostigmine test enabled the diagnosis of MG.The condition of the patients improved after treatment with pyridostigmine bromide,glucocorticoids and rituximab.

关 键 词：新斯的明试验 急性髓系白血病 溴吡斯的明 乙酰胆碱受体抗体 利妥昔单抗 重症肌无力 糖皮质激素 异基因造血干细胞移植 

分 类 号：R457.7[医药卫生—治疗学] R746.1[医药卫生—临床医学]