VEGF-C、SDF-1、S1P对慢性心力衰竭患者发生主要不良心血管事件的预测价值  

Predictive value of VEGF-C,SDF-1 and S1P on major adverse cardiovascular events in patients with chronic heart failure

作　　者：梁妍 龙清霞 莫小玲 梁国钦[1] LIANG Yan;LONG Qingxia;MO Xiaoling;LIANG Guoqin(DepartmentⅠof Cardiovascular Medicine,Central People’s Hospital of Zhanjiang,Guangdong,Zhanjiang 524045,China)

机构地区：[1]广东省湛江中心人民医院心内一科,广东湛江524045

出　　处：《中国医药科学》2024年第20期127-130,共4页China Medicine And Pharmacy

基　　金：广东省湛江市科技计划项目(2021B01484)。

摘　　要：目的 探讨血管内皮生长因子C(VEGF-C)、基质细胞衍生因子-1(SDF-1)、1-磷酸鞘氨醇(S1P)对慢性心力衰竭(CHF)患者发生主要不良心血管事件(MACE)的预测价值。方法 选取2021年1月至2023年1月湛江中心人民医院收治的149例CHF患者为研究对象。根据是否发生MACE将患者分为MACE组(54例)和对照组(95例)。比较两组VEGF-C、SDF-1、S1P的水平,采用二元logistic回归分析进行多因素分析,并以ROC曲线评价预测CHF患者发生MACE的价值。结果 MACE组的VEGF-C和S1P水平低于对照组,而SDF-1水平高于对照组,差异有统计学意义(P <0.05)。VEGF-C和S1P均是CHF患者发生MACE的独立保护因素,而SDF-1是CHF患者发生MACE的独立危险因素(P <0.05)。VEGF-C和S1P单独检测的1-AUC分别为0.806和0.811,而SDF-1单独检测的AUC为0.844,VEGF-C、SDF-1、S1P三者联合的AUC为0.938(P <0.01)。结论 VEGF-C、SDF-1、S1P均是CHF患者发生MACE的影响因素,并在MACE的预测中均有一定的价值,其中3种指标联合检测的预测效能最高。Objective To investigate the predictive value of vascular endothelial growth factor C(VEGF-C),stromal cell-derived factor-1(SDF-1)and sphingosine 1-phosphate(S1P)on major adverse cardiovascular events(MACE)in patients with chronic heart failure(CHF).Methods A total of 149 CHF patients admitted to and treated in Central People’s Hospital of Zhanjiang from January 2021 to January 2023 were selected as the research object.According to the occurrence of MACE,patients were divided into the MACE group(n=54)and the control group(n=95).The concentrations of VEGF-C,SDF-1 and S1P between the two groups were detected and compared.Binary logistic regression analysis was used for multivariate analysis,and ROC curve was used to evaluate the value of predicting MACE in CHF patients.Results The levels of VEGF-C and S1P in the MACE group were lower than those in the control group,while the level of SDF-1 was higher than that in the control group,with statistically significant difference(P<0.05).Both VEGF-C and S1P are independent protective factors for MACE in CHF patients,while SDF-1 is an independent risk factor for MACE in CHF patients(P<0.05).The 1-AUC detected separately by VEGF-C and S1P were 0.806 and 0.811,respectively,while that of SDF-1 was 0.844,and the joint AUC of three parties of VEGF-C,SDF-1 and S1P was 0.938(P<0.01).Conclusion VEGF-C,SDF-1 and S1P are influencing factors of MACE in CHF patients,and they all have certain value in the prediction of MACE,in which the combined detection of the three indices has the highest prediction efficiency.

关 键 词：血管内皮生长因子C 基质细胞衍生因子-1 1-磷酸鞘氨醇 慢性心力衰竭 主要不良心血管事件 

分 类 号：R541.6[医药卫生—心血管疾病]