慢性乙型肝炎患者血清GR、FGF-21、DNMT1水平对肝纤维化程度的评估价值  

Evaluation value of serum GR,FGF-21 and DNMT1 levels on the degree of liver fibrosis in patients with chronic hepatitis B

作　　者：刘天保 LIU Tian-bao

机构地区：[1]永煤集团总医院医学检验科,河南永城476600

出　　处：《中国疗养医学》2024年第12期106-109,共4页Chinese Journal of Convalescent Medicine

摘　　要：目的探讨慢性乙型肝炎(CHB)患者血清谷胱甘肽还原酶(GR)、成纤维细胞生长因子21(FGF-21)、DNA甲基化转移酶1(DNMT1)水平对肝纤维化程度的评估价值。方法选取2021年5月至2023年5月于永煤集团总医院诊治的80例CHB患者为研究组,另选取同期健康体检者80例作为对照组。比较两组血清GR、FGF-21、DNMT1水平与HBV-DNA载量。依据肝纤维化程度将研究组患者分为无纤维化17例、轻度纤维化20例、中度纤维化25例、重度纤维化18例。分析血清GR、FGF-21、DNMT1水平与HBV-DNA载量、肝纤维化程度、Child-Pugh分级、炎症分级相关性。采用受试者工作特征曲线(ROC)分析血清GR、FGF-21、DNMT1对肝纤维化程度的评估价值。结果研究组血清GR、DNMT1水平高于对照组,FGF-21水平低于对照组(P<0.05);GR、DNMT1与HBV-DNA载量、肝纤维化程度、Child-Pugh分级、炎症分级呈正相关,而FGF-21与HBV-DNA载量、肝纤维化程度、Child-Pugh分级、炎症分级呈负相关(P<0.05);GR、FGF-21、DNMT1联合检测评估肝纤维化程度的AUC大于单项指标评估(P<0.05)。结论CHB患者血清GR、DNMT1水平升高,FGF-21水平降低,联合检测其水平对肝纤维化程度具有一定评估价值。Objective To investigate the value of serum glutathione reductase(GR),fibroblast growth factor 21(FGF-21)and DNA methyltransferase 1(DNMT1)levels in evaluating the degree of liver fibrosis in patients with chronic hepatitis B(CHB).Methods A total of 80 CHB patients diagnosed and treated in the General Hospital of Yongmei Group from May 2021 to May 2023 were selected as the study group,and another 80 healthy subjects during the same period were selected as the control group.Serum GR,FGF-21,DNMT1 levels and HBV-DNA load were compared between the two groups.According to the degree of liver fibrosis,the study group was divided into 17 cases without fibrosis,20 cases with mild fibrosis,25 cases with moderate fibrosis and 18 cases with severe fibrosis.The correlation between serum GR,FGF-21,DNMT1 levels and HBV-DNA load,liver fibrosis degree,Child-Pugh grade,inflammation grade was analyzed.Receiver operating characteristic curve(ROC)was used to analyze the evaluation value of serum GR,FGF-21 and DNMT1 on the degree of liver fibrosis.Results Serum GR and DNMT1 levels in the study group were higher than those in the control group,and FGF-21 levels were lower than those in the control group(P<0.05).GR and DNMT1 were positively correlated with HBV-DNA load,liver fibrosis degree,Child-Pugh grade and inflammation grade,while FGF-21 was negatively correlated with HBV-DNA load,liver fibrosis degree,Child-Pugh grade and inflammation grade(P<0.05).The AUC of GR,FGF-21 and DNMT1 combined detection was higher than that of single index evaluation(P<0.05).Conclusion Serum GR and DNMT1 levels are increased and FGF-21 levels are decreased in CHB patients.Combined detection of GR,DNMT1 and FGF-21 levels has a certain value in evaluating the degree of liver fibrosis.

关 键 词：慢性乙型肝炎 肝纤维化 谷胱甘肽还原酶 成纤维细胞生长因子21 DNA甲基化转移酶1 

分 类 号：R512.62[医药卫生—内科学]