小儿豉翘清热颗粒联合常规治疗对小儿急性病毒性下呼吸道感染患者的临床疗效  

Clinical effects of Xiao’er Chiqiao Qingre Granules combined with conventional treatment on patients with pediatric acute viral infection of lower respiratory tract

作　　者：孙英楠 杨李 蔡蓓蓓 潘维 SUN Ying-nan;YANG Li;CAI Bei-bei;PAN Wei(Jiading District Central Hospital Affiliated to Shanghai Health Medical College,Shanghai 201800,China)

机构地区：[1]上海健康医学院附属嘉定区中心医院,上海201800

出　　处：《中成药》2024年第11期3640-3644,共5页Chinese Traditional Patent Medicine

基　　金：上海市嘉定区自然科学研究课题项目(JDKW-2020-0020);上海市嘉定区中心医院“双馨培养计划”项目(SX202206)。

摘　　要：目的考察小儿豉翘清热颗粒联合常规治疗对小儿急性病毒性下呼吸道感染患者的临床疗效。方法99例患者随机分为对照组(49例)和观察组(50例),对照组给予常规治疗,观察组在对照组基础上加用小儿豉翘清热颗粒。检测临床疗效、中医证候评分、症状消失时间[退热时间、鼻塞(肺部啰音、喘息、咳嗽)消失时间]、CRP、TNF-α、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、肺功能指标(FEV1、FVC、PEF、MVV)变化。结果观察组总有效率高于对照组(P<0.05),症状消失时间更短(P<0.05)。治疗后,2组中医证候评分、CRP、TNF-α、CD8^(+)降低(P<0.05),CD4^(+)、CD4^(+)/CD8^(+)、肺功能指标升高(P<0.05),以观察组更明显(P<0.05)。结论小儿豉翘清热颗粒联合常规治疗可调节小儿急性病毒性下呼吸道感染患者机体免疫,降低CRP、TNF-α水平,减少炎症损伤,改善肺功能,缓解病情,提升临床疗效。AIM To investigate the clinical effects of Xiao’er Chiqiao Qingre Granules combined with conventional treatment on patients with pediatric acute viral infection of lower respiratory tract.METHODS Ninety-nine patients were randomly assigned into control group(49 cases)for intervention of conventional treatment,and observation group(50 cases)for intervention of both Xiao’er Chiqiao Qingre Granules and conventional treatment.The changes in clinical effects,TCM syndrome scores,symptom disappearing time[fever reduction time,nasal congestion(lung rales,wheezing,cough)disappearance time],CRP,TNF-α,CD4^(+),CD8^(+),CD4^(+)/CD8^(+)and lung function indices(FEV1,FVC,PEF,MVV)were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05),along with shorter symptom disappearing time(P<0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,CRP,TNF-α,CD8^(+)(P<0.05),and increased CD4^(+),CD4^(+)/CD8^(+),lung function indices(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with pediatric acute viral infection of lower respiratory tract,Xiao’er Chiqiao Qingre Granules combined with conventional treatment can regulate body immunity,decrease CRP,TNF-αlevels,reduce inflammatory injury.

关 键 词：小儿豉翘清热颗粒 常规治疗 小儿急性病毒性下呼吸道感染 

分 类 号：R287[医药卫生—中药学]