真武汤联合丹参饮对慢性心力衰竭患者的临床疗效  

Clinical effects of Zhenwu Decoction combined with Danshen Drink on patients with chronic heart failure

作　　者：马晓升 张迪 马晶 刑春旭 陈光 MA Xiao-sheng;ZHANG Di;MA Jing;XING Chun-xu;CHEN Guang(Department of Cardiology,The Second Hospital Affiliated to Mudanjiang Medical College,Mudanjiang 157000,China;Department of Endocrinology and Hematology,The Second People’s Hospital of Mudanjiang,Mudanjiang 157013,China;Department of Renal Endocrinology,The Second Hospital Affiliated to Mudanjiang Medical College,Mudanjiang 157000,China;Department of Traditional Chinese Medicine,The Second Hospital Affiliated to Mudanjiang Medical College,Mudanjiang 157000,China;Department of Hematology and Rheumatology,The Second Hospital Affiliated to Mudanjiang Medical College,Mudanjiang 157000,China)

机构地区：[1]牡丹江医学院附属第二医院心内科,黑龙江牡丹江157000 [2]牡丹江市第二人民医院内分泌血液科,黑龙江牡丹江157013 [3]牡丹江医学院附属第二医院肾内内分泌科,黑龙江牡丹江157000 [4]牡丹江医学院附属第二医院中医科,黑龙江牡丹江157000 [5]牡丹江医学院附属第二医院血液风湿科,黑龙江牡丹江157000

出　　处：《中成药》2024年第11期3651-3654,共4页Chinese Traditional Patent Medicine

基　　金：黑龙江省卫生健康委科研课题(2020-399)。

摘　　要：目的探讨真武汤联合丹参饮对慢性心力衰竭患者的临床疗效。方法86例患者随机分为对照组和观察组,每组43例,对照组给予常规治疗,观察组在对照组基础上加用真武汤联合丹参饮,疗程4周。检测心功能指标(LVFS、LVEDD、LVEF)、血清指标(hs-cTnI、sST2、NT-proBNP、MMP-9)、炎症因子(IL-6、TNF-α、hs-CRP)、血小板聚集率、QTcd、不良反应发生率变化。结果治疗后,2组LVFS、LVEF升高(P<0.05),LVEDD、血清指标、炎症因子、血小板聚集率、QTcd降低(P<0.05),以观察组更明显(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论真武汤联合丹参饮可安全有效地改善慢性心力衰竭患者hs-cTnI水平和血小板聚集功能。AIM To explore the clinical effects of Zhenwu Decoction combined with Danshen Drink on patients with chronic heart failure.METHODS Eighty-six patients were randomly assigned into control group(43 cases)for 4-week intervention of conventional treatment,and observation group(43 cases)for 4-week intervention of Zhenwu Decoction,Danshen Drink and conventional treatment.The changes in cardiac function indices(LVFS,LVEDD,LVEF),serum indices(hs-cTnI,sST2,NT-proBNP,MMP-9),inflammatory factors(IL-6,TNF-α,hs-CRP),platelet aggregation rate,QTcd and incidence of adverse reactions were detected.RESULTS After the treatment,the two groups demonstrated increased LVFS,LVEF(P<0.05),and decreased LVEDD,serum indices,inflammatory factors,platelet aggregation rate,QTcd(P<0.05),especially for the observation group(P<0.05).No significant difference in incidence of adverse reactions was found between the two groups(P>0.05).CONCLUSION For the patients with chronic heart failure,Zhenwu Decoction combined with Danshen Drink can safely and effectively improve hs-cTnI level and platelet aggregation functions.

关 键 词：真武汤 丹参饮 常规治疗 慢性心力衰竭 

分 类 号：R287[医药卫生—中药学]