药食同源中草药通过肠道菌群调控代谢性疾病研究进展  

Research progress on regulation of metabolic diseases by intestinal flora of homologous Chinese herbs in medicine and herbs

作　　者：刘玺元 曾天 李昀晏 吴刚[1] 赵鑫[2] 伊扬磊 LIU Xiyuan;ZENG Tian;LI Yunyan;WU Gang;ZHAO Xin;YI Yanglei(College of Food Science and Engineering,Northwest A&F University,Yangling 712100,China;Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]西北农林科技大学食品科学与工程学院,杨凌712100 [2]天津中医药大学中医药研究院,天津301617

出　　处：《天津中医药》2024年第11期1482-1490,共9页Tianjin Journal of Traditional Chinese Medicine

基　　金：组分中药国家重点实验室开放课题(CBCM2020204)。

摘　　要：近年来,代谢性疾病,如肥胖、2型糖尿病和非酒精性脂肪肝等高发,对国民健康造成严峻挑战。研究人员逐渐认识到肠道菌群的重要性,菌群结构和功能紊乱与上述疾病的发生发展具有密切联系。研究发现,一些具有药食同源特性的中草药活性成分,如多酚类和皂苷类等,可通过改善肠道菌群结构和功能,调节机体代谢过程,发挥治疗作用。这些药食同源中草药在预防和治疗代谢性疾病方面显示出巨大潜力。文章总结了当前有关药食同源中草药提取物通过调节肠道菌群来治疗和预防代谢性疾病的原理和方法,为饮食干预代谢性疾病和开发功能性食品提供参考。In recent years,metabolic diseases such as obesity,type 2 diabetes,and non-alcoholic fatty liver disease have become prevalent,posing a serious challenge to public health.Researchers have gradually recognized the importance of the gut microbiota,as disruptions in its structure and function are closely linked to the development of these diseases.Studies have found that some bioactive components of traditional Chinese herbs,such as polyphenols and saponins,which have the characteristics of“medicinal and edible homology”,can improve the structure and function of the gut microbiota,regulate metabolic processes,and exert therapeutic effects.These medicinal and edible homologous Chinese herbs show great potential in the prevention and treatment of metabolic diseases.The article summarized the principles and methods of using extracts from medicinal and edible homologous Chinese herbs to regulate the gut microbiota for the treatment and prevention of metabolic diseases,providing references for dietary intervention in metabolic diseases and the development of functional foods.

关 键 词：药食同源中草药 肠道菌群 黄酮 多糖 生物碱 皂苷 

分 类 号：R589[医药卫生—内分泌]