老年T2DMCT冠脉钙化积分与动脉粥样硬化的分析及预测冠脉事件的作用探究  

Analysis of CT Coronary Artery Calcification Score and Atherosclerosis in Elderly Patients with T2DM and Its Role in Predicting Coronary Events

作　　者：史斌 巫迎春 赵志维 邵元伟 徐雪颖 Shi Bin;Wu Ying-chun;Zhao Zhi-wei;Shao Yuan-wei;Xu Xue-ying(Imaging Department of Jiangsu University Affiliated Hospital,Zhenjiang 212000,Jiangsu Province,China)

机构地区：[1]江苏大学附属医院影像科,江苏镇江212000

出　　处：《中国CT和MRI杂志》2024年第11期66-68,105,共4页Chinese Journal of CT and MRI

基　　金：江苏省卫生健康委医学科研课题(ZD20210022)。

摘　　要：目的分析老年2型糖尿病(T2DM)患者CT冠脉钙化积分与动脉粥样硬化的关系,并探究其对冠脉事件的预测价值。方法选取2020年6月-2022年6月医院126例T2DM患者为研究对象,所有患者均接受CT扫描检查,计算冠脉钙化积分,并依据冠脉钙化积分将患者分为≤100HU组与>100HU组,对比两组患者冠状动脉粥样硬化亚临床指标(内膜-中层厚度、斑块总面积、斑块最大厚度、斑块数量),采用Pearson相关性分析T2DM患者CT冠脉钙化积分与冠状动脉粥样硬化亚临床指标的关系。随访1年,统计T2DM患者冠脉事件发生状况,并将其分为发生组与未发生组,对比两组冠脉钙化积分,绘制受试者工作特征曲线(ROC)分析其对冠脉事件的预测价值。结果126例T2DM患者冠脉钙化积分为(98.52±11.53)HU,其中≤100HU69例(54.76%),>100HU57例(45.24%);>100HU组内膜-中层厚度、斑块总面积、斑块最大厚度大于≤100HU组,斑块数量多与≤100HU组(P<0.05);经Pearson相关性分析,结果显示,CT冠脉钙化积分与内膜-中层厚度、斑块总面积、斑块最大厚度、斑块数量呈正相关(r>0,P<0.05);随访1年,126例T2DM患者中发生冠脉事件23例,占18.25%;发生组冠脉钙化积分高于未发生组(P<0.05);经Logistic回归分析,结果显示,冠脉钙化积分是T2DM患者发生冠脉事件的危险因素(OR>1,P<0.05);绘制ROC曲线发现,冠脉钙化积分对T2DM患者发生冠脉事件具有一定预测价值(AUC=0.765)。结论老年T2DM患者CT冠脉钙化积分与动脉粥样硬化密切相关,同时CT冠脉钙化积分在预测冠脉事件中具有良好应用价值。Objective To analyze the relationship between CT coronary artery calcification score and atherosclerosis in elderly patients with type 2 diabetes mellitus(T2DM),and to explore its predictive value for coronary events.Methods A total of 126 T2DM patients in the hospital from June 2020 to June 2022 were selected as the study objects.All patients were examined by CT scan,and the coronary calcification scores were calculated,and the patients were divided into≤100HU group and>100HU group according to the coronary calcification scores.The subclinical indicators of coronary atherosclerosis(intima-media thickness,total plaque area,maximum plaque thickness,and number of plaques)were compared between the two groups.Pearson correlation was used to analyze the relationship between CT coronary artery calcification score and subclinical indicators of coronary atherosclerosis in T2DM patients.Patients with T2DM were followed up for 1 year,and the occurrence of coronary events was statistically analyzed,and the patients were divided into occurrence group and non-occurrence group.The coronary calcification scores of the two groups were compared,and the predictive value of coronary events was analyzed by receiver operating characteristic curve(ROC).Results The coronary calcium scores of 126 patients with T2DM were(98.52±11.53)HU,of which≤100HU69(54.76%)and>100HU57(45.24%).The intima-media thickness,total patch area and maximum patch thickness in the>100HU group were greater than those in the≤100HU group,and the number of plaques was more than that in the≤100HU group(P<0.05).Pearson correlation analysis showed that CT coronary calcification score was positively correlated with intima-media thickness,total plaque area,maximum plaque thickness and plaque number(r>0,P<0.05).After 1 year of follow-up,23 cases(18.25%)of 126 T2DM patients had coronary events.The score of coronary artery calcification in the occurrence group was higher than that in the non-occurrence group(P<0.05).Logistic regression analysis showed that coronary

关 键 词：2型糖尿病 CT冠脉钙化积分 动脉粥样硬化 冠脉事件 

分 类 号：R445[医药卫生—影像医学与核医学]