浸润性乳腺癌磁共振特征与分子分型的相关性研究  

Study on Correlation between Magnetic Resonance Characteristics and Molecular Typing of Invasive Breast Cancer

作　　者：周小忠 黄鑫 刘德樟 ZHOU Xiao-zhong;HUANG Xin;LIU De-zhang(Department of Imaging,Guidong People's Hospital of Guangxi Zhuang Autonomous Region,Wuzhou 543001,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西壮族自治区桂东人民医院影像科,广西梧州543001

出　　处：《中国CT和MRI杂志》2024年第11期85-88,共4页Chinese Journal of CT and MRI

基　　金：贺州市科学研究与技术开发计划项目(贺科技202273)。

摘　　要：目的通过分析浸润性乳腺癌磁共振特征与分子分型的相关性,探讨磁共振特征对浸润性乳腺癌分子分型的诊断价值。方法回顾性分析165例本院临床确诊为浸润性乳腺癌患者的病理、磁共振资料,根据免疫组化结果分为四个分子分型,比较不同分子分型的磁共振特征差异,多因素Logistic回归分析四个分子分型的影响因素。结果165例浸润性乳腺癌患者以Luminal B型发病最常见。四个分子分型在形状、边缘、强化均匀性、MIP和大小方面的差异具有统计学意义(P<0.05)。MIP血管增粗是Luminal A型的独立保护因素;边缘有毛刺是Luminal B型的独立危险因素,直径较大、ADC值较高均是Luminal B型的独立保护因素;病灶呈多灶性、直径较大均是HER-2过表达型的独立危险因素;瘤周水肿、直径较大均是三阴性型的独立危险因素,形状不规则形是三阴性型的独立保护因素;以上P值均<0.05。结论浸润性乳腺癌磁共振特征与分子分型具有相关性、存在相关的独立影响因素,能为分子分型诊断提供影像学预测价值。Objective To explore the diagnostic value of MRI features for molecular subtypes of invasive breast cancer by analyzing the correlation between MRI features and molecular subtypes of invasive breast cancer.Methods The pathological and MRI data of 165 patients with clinically diagnosed invasive breast cancer in our hospital were retrospectively analyzed.According to the immunohistochemical results,it is divided into four molecular subtypes.The MRI features of different molecular subtypes were compared,and the influencing factors of the four molecular subtypes were analyzed by multivariate Logistic regression.Results Luminal B was the most common subtype of invasive breast cancer in 165 patients.There were significant differences in shape,margin,enhancement uniformity,MIP and size among the four molecular subtypes(P<0.05).MIP vessel thickening was an independent protective factor for Luminal A subtype;Spiculated edge was an independent risk factor for Luminal B subtype,Larger diameter and higher ADC value were independent protective factors for Luminal B subtype;Multifocality and larger diameter were independent risk factors for HER-2 overexpression;Peritumoral edema and larger diameter were independent risk factors for triple-negative type,Irregular shape was an independent protective factor for triple-negative type,All the above P values were<0.05.Conclusion MRI features of invasive breast cancer are correlated with molecular subtype,and there are related independent influencing factors,which can provide imaging predictive value for molecular subtype diagnosis.

关 键 词：分子分型 浸润性乳腺癌 磁共振 LOGISTIC回归分析 

分 类 号：R445.2[医药卫生—影像医学与核医学]