MR成像对2型糖尿病的异位脂肪沉积的量化及相关因素分析  

MR Imaging Quantification of Ectopic Fat Deposition in Type 2 Diabetes Mellitus and Analysis of Related Factors

作　　者：周心荷 符兆坚 罗松 李淳娥 马继孔 ZHOU Xin-he;FU Zhao-jian;LUO Song;LI Chun-e;MA Ji-kong(School of Clinical Medicine,Dali University,Dali 671000,Yunnan Province,China;Department of Ultrasound,Affiliated Hospital of Chengdu University,Chengdu 610000,Sichuan Province,China;Department of Science and Education,Dali Bai Autonomous Prefecture People's Hospital(The Third Affiliated Hospital of Dali University),Dali 671000,Yunnan Province,China;Department of Radiology,Dali Bai Autonomous Prefecture People's Hospital(The Third Affiliated Hospital of Dali University),Dali 671000,Yunnan Province,China;Department of Endocrinology,Dali Bai Autonomous Prefecture People's Hospital(The Third Affiliated Hospital of Dali University),Dali 671000,Yunnan Province,China;Department of Nephrology,Dali Bai Autonomous Prefecture People's Hospital(The Third Affiliated Hospital of Dali University),Dali 671000,Yunnan Province,China)

机构地区：[1]大理大学临床医学院,云南大理671000 [2]成都大学附属医院超声科,四川成都610000 [3]大理白族自治州人民医院(大理大学第三附属医院)科教科,云南大理671000 [4]大理白族自治州人民医院(大理大学第三附属医院)放射科,云南大理671000 [5]大理白族自治州人民医院(大理大学第三附属医院)内分泌科,云南大理671000 [6]大理白族自治州人民医院(大理大学第三附属医院)肾内科,云南大理671000

出　　处：《中国CT和MRI杂志》2024年第11期147-150,共4页Chinese Journal of CT and MRI

基　　金：云南省教育厅科学研究基金项目资助(2021J0369)。

摘　　要：目的本研究旨在分析初诊2型糖尿病患者肝脏、胰腺、肾脏脂肪含量变化及相关影响因素。方法收集临床初诊为2型糖尿病的患者60名及正常受试者31名。采用3.0T MR WFS技术分别测量并比较两组受试者的肝脏、胰腺及肾脏的脂肪分数;分析糖尿病组各器官脂肪含量与相关实验室指标的相关性。结果初诊2型糖尿病组的肝脏、胰腺及肾脏脂肪分数分别高于正常组,差异具有统计学意义(P<0.05);2型糖尿病组肝脏脂肪分数与身体质量指数(BMI)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)呈正相关(r=0.40、0.28、0.41,P<0.01);胰腺脂肪分数与年龄、BMI呈正相关(r=0.41、0.32,P<0.01);肾脏脂肪分数与FINS、HOMA-IR呈正相关(r=0.30、0.36,P<0.01)。结论与健康对照组相比,患有2型糖尿病患者的肝脏、胰腺及肾脏脂肪含量增加;并且肝脏、胰腺及肾脏脂肪含量的增高与2型糖尿病的发生存在密切关联,MRI-WFS序列有助于器官脂肪含量的测定。Objective To quantify the fat content of liver,pancreas and kidney and analyze related influencing factors in newly diagnosed type 2 diabetes patients.Methods This study included 60 patients with type 2 diabetes who were newly diagnosed and 31 volunteers.The 3.0T MR WFS technology was used to measure and compare the fat fractions of the liver,pancreas and renal of the two groups.The correlation between the fat content of each organ and related laboratory indexes in the diabetic group was analyzed.Results The liver,pancreas and renal fat fractions of the newly diagnosed type 2 diabetes group were higher than those of the normal group,with statistically significant differences(P<0.05).Liver fat fraction is related to BMI(r=0.40,P<0.01),FINS(r=0.28,P<0.01),HOMA-IR(r=0.41,P<0.01);pancreatic fat fraction and age(r=0.41,P<0.01),BMI(r=0.32,P<0.01)were positively correlated;renal fat fraction was positively correlated with FINS and HOMA-IR(r=0.30,0.36,P<0.01).Conclusion In 3.0T MRI,the liver,pancreas,and renal fat of patients with type 2 diabetes increased compared with healthy controls.The fat content of liver,pancreas and kidney fat is closely related to the occurrence of type 2 diabetes.MRI-WFS sequence is helpful for the quantification of organ fat content.

关 键 词：2型糖尿病 肝脏 胰腺 肾脏 异位脂肪沉积 磁共振成像 WFS技术 

分 类 号：R445.2[医药卫生—影像医学与核医学] R587.1[医药卫生—诊断学]