载姜黄素PA6纳米纤维纱线的制备及性能研究  

Preparation and Property Study of Curcumin-loaded PA6 Nanofiber Yarns

作　　者：潘敏 吴海波[1,2] 刘万军 PAN Min;WU Hai-bo;LIU Wan-jun(Engineering Research Center of Technical Textiles,Ministry of Education,Donghua University,Shanghai 201620;Key Laboratory of Textile Science&Technology,Ministry of Education,Donghua University,Shang-hai 201620;Shanghai Engineering Technology Research Center of Nano-biomaterials and Regenerative Medi-cine,Shanghai 201620)

机构地区：[1]东华大学产业用纺织品教育部工程研究中心,上海201620 [2]东华大学纺织面料技术教育部重点实验室,上海201620 [3]上海纳米生物材料与再生医学工程技术研究中心,上海201620

出　　处：《纺织科学与工程学报》2024年第4期5-10,共6页Journal of Textile Science and Engineering

基　　金：国家自然科学基金项目(32271422,32311530766)。

摘　　要：纳米纤维纱线作为一种新兴的纳米材料,不仅具有传统纳米纤维的高比表面积性能优势,而且具有优异的力学和二次加工性能。利用水浴法静电纺纱制备了具有良好取向的载姜黄素纳米纤维纱线,采用扫描电镜(SEM)、体式显微镜、傅里叶变换红外光谱(FTIR)、紫外—可见光(UV-Vis),系统表征和分析了载药纳米纤维纱线的结构性能。结果表明:增加姜黄素的浓度不会影响纳米纤维纱线的粗细,但会影响纳米纤维纱线结构,降低纱线内部孔隙,制得的载药纳米纤维纱线的干强高达10.4 MPa,湿强可达9.7 MPa,在200 h内累计药物释药百分率可达55.67%。Nanofiber yarn,as an emerging nanomaterial,not only has the advantage of high specific surface area property of traditional nanofibers,but also has excellent mechanical and secondary processing properties.In this paper,water bath electrospinning yarn fabrication technology was utilized to prepare curcumin-loaded nanofiber yarns with good orientation.The structural properties of drug-loaded nanofiber yarn were systematically characterized and analyzed by using scanning electron microscopy(SEM),stereomicroscope,Fourier transform infrared spectroscopy(FTIR)and ultraviolet-visible light(UV-Vis).Results indicated that the increase of the curcumin concentration didn’t affect the thickness of nanofiber yarns,but could affect the structure of nanofiber yarns and reduce the internal pores of the yarns.The dry strength of the prepared drug-loaded nanofiber yarn could reach up to 10.4 MPa and the wet strength could reach 9.7 MPa.The cumulative drug release rate within 200 h could reach 55.67%.

关 键 词：静电纺 纳米纤维纱线 姜黄素 药物缓释 

分 类 号：TS106.4[轻工技术与工程—纺织工程] TQ340.64[轻工技术与工程—纺织科学与工程]