免疫代谢物衣康酸对不同疾病调控作用及其作用机制研究进展  

Advancements in the regulatory effects and mechanisms of the immune metabolite itaconate in diseases

作　　者：程钟坤 赵静贤 刘言言 徐凌 赵光伟[1] 倪兴维 杨晓伟[1] CHENG Zhongkun;ZHAO Jingxian;LIU Yanyan;XU Ling;ZHAO Guangwei;NI Xingwei;YANG Xiaowei(College of Veterinary Medicine,Southwest University,Chongqing 402460,China;Animal Disease Prevention and Control Center of Guizhou Province,Guiyang 550008,Guizhou,China)

机构地区：[1]西南大学动物医学院,重庆402460 [2]贵州省动物疫病预防控制中心,贵州贵阳550008

出　　处：《生物工程学报》2024年第11期3888-3901,共14页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(32002356);重庆市自然科学基金(cstc2019jcyj-msxmX0140);贵州省科技支撑项目(黔科合支撑[2023]一般022)。

摘　　要：衣康酸(itaconate)是免疫细胞三羧酸(tricarboxylic acid,TCA)循环的一种重要中间代谢物,由免疫应答基因1(immune response gene 1,IRG1)编码的乌头酸脱羧酶1(aconitate decarboxylase1,ACOD1)催化顺乌头酸脱羧产生,其通过调控炎症、重塑细胞代谢和参与遗传调控等方式在不同疾病中发挥重要调控作用。本文综述了衣康酸的结构、对不同疾病调控作用及其作用机制为衣康酸相关药物的研发提供理论依据。Itaconate is a pivotal intermediate metabolite in the tricarboxylic acid(TCA)cycle of immune cells.It is produced by decarboxylation of cis-aconitic acid under the catalysis of aconitate decarboxylase 1(ACOD1),which is encoded by the immune response gene 1(IRG1).Itaconate has become a focal point of research on immunometabolism.Studies have demonstrated that itaconate plays a crucial role in diseases by regulating inflammation,remodeling cell metabolism,and participating in epigenetic regulation.This paper reviewed the research progress in itaconnate from its chemical structure,regulatory effects on different diseases,and mechanisms,proposes the future research directions,aiming to provide a theoretical basis for the development of itaconate-related drugs.

关 键 词：衣康酸 免疫 代谢物 炎症 细胞代谢 遗传调控 

分 类 号：S852.4[农业科学—基础兽医学]