基于线粒体自噬探讨中医药干预糖尿病肾病的研究进展  

Research Progress on Traditional Chinese Medicine Intervention in Diabetic Nephropathy Based on Mitophagy

作　　者：何亚萍 贾登科 陈文英 刘存蓉 刘娟[1] 史晓伟[3] HE Yaping;JIA Dengke;CHEN Wenying;LIU Cunrong;LIU Juan;SHI Xiaowei(Gansu University of Chinese Medicine,Lanzhou 730000,China;Lanzhou University,Lanzhou 730000,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]兰州大学,甘肃兰州730000 [3]甘肃省中医院,甘肃兰州730050

出　　处：《中医药信息》2024年第11期72-78,共7页Information on Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81960888,82360884,82360955);甘肃省科协青年科技人才托举工程项目(GXH202026-11);兰州市人才创新创业项目(2019-RC-62)。

摘　　要：糖尿病肾病(DKD)是指由糖尿病所致的慢性肾脏病,也是导致终末期肾脏病的主要原因,目前仍缺乏有效的治疗手段。糖尿病肾病中能量底物利用的病理变化可导致线粒体功能障碍和代谢异常,线粒体自噬能够清除受损或老化的线粒体来维持线粒体的健康状态,对减轻高糖引起的肾脏损伤至关重要。笔者通过查阅国内外相关文献,从线粒体DNA损伤、内质网应激、氧化应激、铁死亡以及相关信号通路出发,发现中药单体、中药复方及针灸等能够通过调控线粒体自噬,如调节线粒体DNA损伤、调节内质网应激、调节缺氧状态、调节氧化应激、调节铁死亡、协调线粒体自噬相关信号通路的表达等。Diabetic nephropathy(DKD)refers to chronic kidney disease caused by diabetes and is the leading cause of end-stage renal disease.Currently,effective treatments for DKD remain lacking.Pathological changes in energy substrate utilization in diabetic nephropathy can lead to mitochondrial dysfunction and metabolic abnormalities.Mitophagy,which eliminates damaged or aging mitochondria to maintain mitochondrial health,is crucial for alleviating kidney damage induced by hyperglycemia.By reviewing relevant literature both domestically and internationally,the authors found that traditional Chinese medicine monomers,traditional Chinese medicinal formulas,and acupuncture can regulate mitophagy by modulating mitochondrial DNA damage,endoplasmic reticulum stress,hypoxia,oxidative stress,ferroptosis,and the expression of related signaling pathways.

关 键 词：线粒体自噬 糖尿病肾病 信号通路 中医药 调节机制 

分 类 号：R259[医药卫生—中西医结合] R277.5[医药卫生—中医内科学]