甘油三酯葡萄糖乘积指数与肾结石的相关性研究  

Study on the correlation between triglyceride glucose product index and kidney stones

作　　者：熊紫君 何应梅 袁平[1] 何福逵 余可斐 刘冰[1] XIONG Zi-jun;HE Ying-mei;YUAN Ping;HE Fu-kui;YU Ke-fei;LIU Bing(School of Public Health and Health,Hubei University of Medicine,Shiyan,Hubei 442000,China;不详)

机构地区：[1]湖北医药学院公共卫生与健康学院,湖北十堰442000 [2]十堰市太和医院·湖北医药学院附属医院,湖北十堰442000

出　　处：《现代预防医学》2024年第21期4022-4026,共5页Modern Preventive Medicine

摘　　要：目的探讨甘油三酯葡萄糖乘积指数(triglyceride glucose,TyG)与肾结石的相关性。方法基于2022年湖北某建筑公司职工年度体检数据,依据有无肾结石,将研究对象分为肾结石组(n=854)和非肾结石组(n=1636)。运用描述统计、χ2检验、多因素logistic回归分析,评估TyG指数与肾结石风险的相关性。结果共纳入2490例研究对象,肾结石组年龄、身体质量指数(body mass index,BMI)、TyG指数、尿酸、总胆固醇、甘油三酯、低密度脂蛋白、舒张压、空腹血糖水平均高于非肾结石组(P<0.05)。多因素logistic回归分析显示,TyG指数第2、3、4四分位组肾结石患病风险分别是第1四分位组的1.071倍(OR=1.071,95%CI:0.822~1.394,P<0.612)、1.174倍(OR=1.174,95%CI:0.886~1.556,P<0.263)和1.851倍(OR=1.851,95%CI:1.342~2.553,P<0.001),TyG指数越高肾结石患病风险越大(χ^(2)=37.146,P<0.001),提示TyG指数是肾结石发生的危险因素,并存在明显的线性关系。亚组分析表明,在超重肥胖人群(OR=1.494,95%CI:1.245~1.794,P<0.001)及高脂血症人群(OR=2.047,95%CI:1.606~2.61,P<0.001)中,TyG指数与肾结石风险仍呈正相关(P<0.05)。结论较高的TyG指数与肾结石的患病风险增加有关,早期干预胰岛素抵抗(insulin resistance,IR)可能有助于改善或降低肾结石发病风险。Objective To investigate the correlation between the triglyceride glucose product index(TyG)and kidney stones.Methods Based on the annual health check-up data of employees from a construction company in Hubei in 2022,subjects were divided into kidney stone group(n=854)and non-kidney stone group(n=1636)according to the presence of kidney stones.Descriptive statistics,chi-square tests,and multivariable logistic regression analyses were employed to assess the cor-relation between the TyG index and the risk of kidney stones.Results A total of 2490 subjects were included in the study.The kidney stone group had higher levels of age,body mass index(BMI),TyG index,uric acid,total cholesterol,triglycerides,low-density lipoprotein,diastolic blood pressure,and fasting blood glucose compared to the non-kidney stone group(P<0.05).Multivariable logistic regression analysis indicated that the risk of kidney stones for the 2nd,3rd,and 4thquartiles of the TyG index was 1.071 times(OR=1.071,95%CI:0.822-1.394,P<0.612),1.174 times(OR=1.174,95%CI:0.886-1.556,P<0.263),and 1.851 times(OR=1.851,95%CI:1.342-2.553,P<0.001)that of the first quartile,respectively.Higher TyG index levels were associated with an increased risk of kidney stones(χ~2=37.146,P<0.001),indicating that the TyG index was a risk factor for the occurrence of kidney stones with a significant linear relationship.Subgroup analysis revealed that in overweight and obese populations(OR=1.494,95%CI:1.245-1.794,P<0.001)and in populations with hyperlipidemia(OR=2.047,95%CI:1.606-2.61,P<0.001),the TyG index remained positively correlated with the risk of kidney stones(P<0.05).Conclusion A higher TyG index is associated with an increased risk of kidney stones,and early intervention in insulin resistance may help improve or reduce the incidence risk of kidney stones.

关 键 词：甘油三酯葡萄糖乘积指数 肾结石 胰岛素抵抗 

分 类 号：R692.4[医药卫生—泌尿科学]