肾移植中补体激活的研究进展  

Update on complement activation in kidney transplantation

作　　者：张淑宇(综述) 李月红(审校)[1] ZHANG Shuyu;LI Yuehong(Beijing Tsinghua Changgung Hospital,Tsinghua Clinical Medical School,Tsinghua University,Beijing 102218,China)

机构地区：[1]清华大学附属北京清华长庚医院肾内科,北京102218

出　　处：《肾脏病与透析肾移植杂志》2024年第5期490-494,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：北京市医管局扬帆计划(YGLX202332)。

摘　　要：肾移植是终末期肾脏病最有效的替代治疗方法,但其受限于供者数量不足、免疫抑制负担和移植肾失功等因素。补体激活发生在肾移植不同阶段,始于供者并在缺血后再灌注时再次发生,可促进同种免疫反应的发生发展,在急性和慢性同种异体移植肾排斥反应期间直接导致移植肾损伤。本文总结了补体激活在肾移植中研究进展,以针对性应对移植过程中肾损伤,从而提高移植肾的存活率。The kidney transplantation is one of the best treatments for end stage kidney disease,the benefits are limited by factors such as the short fall in donor numbers,immunosuppression burden and graft failure.The complement activation occurs at many stages during transplantation,begins in the donor and occurs again on reperfusion following a period of ischemia.Complement activation can contribute to the development of the alloimmune response and may directly contribute to graft injury during acute and chronic allograft rejection.The article aims to summarize the recent progress of complement activation in kidney transplantation,in order to better intervene the graft injury in different stages of transplantation,and the survival rate of graft can be improved.

关 键 词：肾移植 补体 缺血再灌注损伤 抗体介导的排斥反应 T细胞介导的排斥反应 

分 类 号：R699.2[医药卫生—泌尿科学]