狼疮性肾炎伴癫痫发作、反复腹痛呕吐  

Lupus nephritis with epilepsy,recurrent abdominal pain and vomiting

作　　者：李莉[1] 周琳珊 杨淡昳[1] 查杰 朱雪婧[1] 刘虹[1] 陈国纯[1] LI Li;ZHOU Linshan;YANG Danyi;ZHA Jie;ZHU Xuejing;LIU Hong;CHEN Guochun(Department of Nephrology,the Second Xiangya Hospital of Central South University,Hunan Key Laboratory of Kidney Disease and Blood Purification,the Second Xiangya Hospital of Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院肾内科,长沙410011

出　　处：《肾脏病与透析肾移植杂志》2024年第5期495-500,共6页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金项目(82170759);湖南省自然科学基金(2023JJ30744)。

摘　　要：青年女性系统性红斑狼疮(SLE)患者,以肾病综合征起病,治疗过程中病情变化,出现狼疮脑病、肠系膜血管炎及急性胰腺炎等并发症,经大剂量激素冲击联合环磷酰胺、血浆置换、血液滤过及单抗类药物序贯治疗达到完全缓解。T细胞亚群分型检测有助于鉴别诊断重症SLE合并多系统受累与感染、药物不良反应等严重合并症。A 17-year-old female with systemic lupus erythematosus,who presented with nephrotic syndrome at onset,developed lupus encephalopathy,mesenteric vasculitis,and acute pancreatitis during treatment.She received methylprednisolone pulses and cyclophosphamide,plasma exchange,and hemofiltration and sequential B cell-targeting therapies,and achieved complete remission.Identification of T cell subpopulation changes is helpful in this case for the differential diagnosis of severe SLE complicated with multi-system involvement and other complications,such as infection and adverse drug reactions.

关 键 词：系统性红斑狼疮 狼疮肠系膜血管炎 急性胰腺炎 T细胞亚群 

分 类 号：R593.242[医药卫生—内科学] R742.1[医药卫生—临床医学]