色素颗粒是皮肤型红斑狼疮的敏感性皮肤镜特征  

Pigment granules are sensitivity dermatoscopic feature in diagnosis cutaneous lupus erythematosus

作　　者：鲁丽霞[1,2,3] 赵雪 陈明亮 陈翔[1,2,3] 粟娟 LU LiXia;ZHAO Xue;CHEN MingLiang;CHEN Xiang;&SU Juan(Hunan Key Laboratory of Skin Cancer and Psoriasis,Department of Dermatology,Xiangya Hospital,Central South University,Changsha 410008,China;Hunan Engineering Research Center of Skin Health and Disease,Changsha 410008,China;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Changsha 410008 China)

机构地区：[1]中南大学湘雅医院皮肤科,皮肤肿瘤与银屑病湖南省重点实验室,长沙410008 [2]湖南省皮肤健康与疾病工程研究中心,长沙410008 [3]国家老年疾病临床研究中心,中南大学湘雅医院,长沙410008

出　　处：《中国科学：生命科学》2024年第11期2181-2187,共7页Scientia Sinica(Vitae)

摘　　要：皮肤型红斑狼疮(cutaneous lupus erythematosus,CLE)的病变具有高度异质性.因为它是根据常见的临床特征和相似的治疗反应进行分类的,病变主要以瘢痕愈合为主.所以CLE的早期诊断至关重要,皮肤镜检查可以实现早期诊断并且有助于评估已有病变的病情.我们采用回顾性分析的方法,分析了90例确诊为CLE的病例,并进行了病理活检和皮肤镜检查.统计病例获得了详细的人口学信息、病理和皮肤镜检查数据,分析发现,色素颗粒、多形性扩张的血管、毛囊角栓和白色无结构区/白色纤维条索是诊断CLE最有特征的皮肤镜表现.多形性血管主要包括蛇形、点状、线状、螺旋状和发夹状等.血管的分布模式主要是在毛囊周围,即红点征,其他分布模式包括局灶分布模式、均匀模式、中心模式、周围分布模式.Lesions of cutaneous lupus erythematosus(CLE)is highly heterogenous.CLE is categorized based on very common features and similar responses to treatment,lesions are mainly heal with scaring.Early diagnosis of CLE is crucial,dermoscopy may enable early diagnosis and help to assess the prognosis of well-established lesions.Retrospective analysis of 90 CLE cases under dermoscopy and pathological biopsy was performed.Cases were reviewed for information regarding pathological and dermoscopy pattern.Dermoscopy was performed using Medicam 800/1000(FotoFinder,Germany)at 20~70×magnification in non-polarized mode.Pigment granules,multiform dilated vessels,follicular keratotic plugs and white structureless areas/white fiber cord are the most featured dermoscopic manifestations in the diagnosis of CLE.The multiform dilated vessels including serpentine,punctate,linear,spiral and hairpin.The distribution pattern of vessels is mainly around follicles,that is red dot sign,other distribution patterns including focal distribution pattern,uniform mode,central mode,peripheral distribution pattern.

关 键 词：皮肤型红斑狼疮 色素颗粒 皮肤镜 组织病理 

分 类 号：R758.62[医药卫生—皮肤病学与性病学]