多功能共轭聚合物在疾病诊疗方面的研究进展  

Recent progress in multi-functional conjugated polymers in the diagnosis and treatment of diseases

作　　者：李玲 唐艳丽[1] Ling Li;Yanli Tang(Key Laboratory of Applied Surface and Colloid Chemistry,Ministry of Education,Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province,School of Chemistry and Chemical Engineering,Shaanxi Normal University,Xi’an 710119,China)

机构地区：[1]应用表面与胶体化学教育部重点实验室,陕西省生命分析化学重点实验室,陕西师范大学化学化工学院,西安710119

出　　处：《中国科学：化学》2024年第10期1644-1662,共19页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:22274095,21974084);中央高校基本科研业务费(编号:GK202302004)资助项目。

摘　　要：共轭聚合物(CPs)是一类具有长程π电子共轭体系的高分子化合物,由于其独特的光物理性质,共轭聚合物已经被广泛应用于生物传感、成像、药物递送、治疗等多个领域.本文从共轭聚合物的结构设计及其应用出发,重点总结了本课题组近年来在多功能共轭聚合物的设计合成及其在疾病诊疗、病原菌杀伤及组织创伤修复领域的应用研究,并探讨了当前研究的主要方向以及所面临的机遇与挑战.Conjugated polymers(CPs) are a class of macromolecules with long-range π-electron conjugation structure.Due to their unique photophysical properties,CPs have been widely used in many fields such as biosensing,imaging,drug delivery and therapy.Based on the structural design and applications of conjugated polymers,this article particularly summarizes recent works in our research group on the design and synthesis of multifunctional conjugated polymers and its applications in the disease diagnosis and treatment,antibacterial and tissue injury repair.In addition,it explores the main direction of current research,as well as opportunities and challenges faced in the future.

关 键 词：共轭聚合物 疾病诊疗 病原菌杀伤 组织创伤修复 

分 类 号：R318[医药卫生—生物医学工程] TQ317[医药卫生—基础医学]