生物活性含硒化合物的荧光成像分析  

Fluorescence imaging of bioactive selenocompounds

作　　者：田勇 张小玲 Yong Tian;Xiaoling Zhang(School of Materials Science and Engineering,College of Physics and Optoelectronic Engineering,Shenzhen University,Shenzhen 518060,China;School of Chemistry and Chemical Engineering,Beijing Institute of Technology,Beijing 102488,China)

机构地区：[1]深圳大学材料学院和物理与光电工程学院,深圳518060 [2]北京理工大学化学与化工学院,北京102488

出　　处：《中国科学：化学》2024年第10期1817-1825,共9页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:22174008);深圳市自然科学基金(编号:JCYJ20210324142211031)资助项目。

摘　　要：硒是一种生命系统内必需的微量元素,并且发挥着至关重要的生物功能.硒的生物功能主要由含硒化合物所承载,具有各种各样的生物功能,如抗氧化、抗炎及促甲状腺激素等功能.目前,绝大多数含硒化合物在不同生理和病理过程中所发挥的具体生物功能仍未明确.因此,探究含硒化合物在不同生理和病理过程中的生物功能受到了极大的关注.近年来,采用荧光探针对含硒化合物进行荧光成像分析的研究方法得到快速发展.本文对这一研究领域的进展进行了概述,根据含硒化合物的种类分为4个部分:(1)硒代半胱氨酸的荧光分析;(2)硒化氢的荧光分析;(3)硫氧还蛋白氧化还原酶的荧光分析;(4)亚硒酸的荧光分析.最后对该领域未来的发展进行了展望.Selenium is an essential trace element in living systems,and performs vital biological functions.The biological functions of selenium are mainly presented by selenocompounds,including antioxidant,anti-inflammatory and enhancing thyroid function.Currently,the specific biological functions of most selenocompounds in different physiological and pathological processes remain unclear.Therefore,exploring the biological functions of selenocompounds in different physiological and pathological processes has received great attention.In recent years,the fluorescence imaging of selenocompounds has been rapidly developed.This review provides an overview of the progress in this research field,which is divided into four sections based on the types of selenocompounds:(1)fluorescence analysis of selenocysteine;(2)fluorescence analysis of hydrogen selenide;(3)fluorescence analysis of thioredoxin oxidoreductase;and(4)fluorescence analysis of selenite.Finally,an outlook on the future development of the field is given.

关 键 词：硒代半胱氨酸 硒化氢 硫氧还蛋白氧化还原酶 亚硒酸 荧光成像 

分 类 号：O657.3[理学—分析化学] Q503[理学—化学]