脂肪肝指数与不同糖代谢人群新发糖尿病风险相关性的研究  

Association between fatty liver index and risk of new onset diabetes in people with different glucose metabolism

作　　者：曲建昌 窦京涛[2] 王安平[2] 谷伟军[2] 吕朝晖[2] 母义明[2] QU Jianchang;DOU Jingtao;WANG Anping(Department of Endocrinology,The 305 Hospital of PLA,Beijing 100017,China)

机构地区：[1]解放军第三〇五医院内分泌科,北京100017 [2]解放军总医院第一医学中心内分泌科

出　　处：《中国糖尿病杂志》2024年第10期726-730,共5页Chinese Journal of Diabetes

基　　金：解放军第三〇五医院院内基金重点项目(21YNZD01)。

摘　　要：目的 探讨脂肪肝指数(FLI)与不同糖代谢人群新发DM风险的相关性.方法 本研究为回顾性队列研究,基线数据来源为"REACTION"研究的北京分中心,并于 3.2 年后进行随访.选取6425 名非DM人群,根据FLI四分位法将所有研究对象分为Q1 组(FLI<11.68,n=1608)、Q2组(11.68≤FLI<24.33,n=1607)、Q3组(24.33≤FLI<44.73,n=1604)、Q4组(FLI≥44.73,n=1606).结果 随访时新发DM 556 例,累积发病率 8.7%.Logistic回归分析显示,对正常糖耐量(NGT)人群或者IGR患者,FLI均是新发DM的危险因素.总体非DM人群中,Q2、Q3、Q4组新发DM风险分别是Q1 组的 1.650 倍(95%CI 1.200~2.290,P=0.002)、2.040 倍(95%CI 1.420~2.940,P<0.001)、2.950 倍(95%CI 1.860~4.670,P<0.001).NGT人群中,Q3、Q4 组新发DM风险分别是Q1 组的1.670倍(95%CI 1.010~2.750,P=0.045)、2.320倍(95%CI 1.410~3.800,P=0.001).FLI是IGR患者进展为DM的危险因素,Q2、Q3、Q4 组进展为DM风险分别是Q1 组的1.480 倍(95%CI 1.080~2.020,P=0.015)、1.620 倍(95%CI 1.190~2.220,P=0.002)、1.630 倍(95%CI 1.180~2.250,P=0.003).结论 NGT人群或IGR患者,FLI与新发DM风险相关,是新发DM的危险因素.Objective To analyze the association between fatty liver index(FLI)and the risk of newly diagnosed diabetes mellitus(DM)in people with different glucose metabolism.Methods A retrospective cohort study was conducted,with baseline data sourced from the Beijing sub center population of the REACTION study.The follow‑up was conducted 3.2 years later.A total of 6425 non DM subjects were included in this study,and divided into four groups using the quartile method based on FLI level:Q1(FLI<11.68,n=1608),Q2(11.68≤FLI<24.33,n=1607),Q3(24.33≤FLI<44.73,n=1604)and Q4(FLI≥44.73,n=1606).Results During follow‑up,a total of 556 new DM patients were found,with a cumulative incidence rate of 8.7%.Logistic regression analysis showed that FLI level was an independent risk factor for new DM patients,whether in non‑DM people,NGT subgroups or IGR subgroups.In non DM population,the risk of developing new DM in the Q1,Q2,Q3 is 1.650 times(95%CI 1.200~2.290,P=0.002),2.040 times(95%CI 1.420~2.940,P<0.001),and 2.950 times(95%CI 1.860~4.670,P<0.001)higher than that in the Q1,respectively.In the NGT population,the risk of newly diagnosed DM in the Q3,Q4 is 1.670 times higher(95%CI 1.010~2.750,P=0.045)and 2.320 times higher(95%CI 1.410~3.800,P=0.001)than that in the first quartile,respectively.FLI level is an independent risk factor for newly diagnosed DM in the IGR population(P=0.012).The risk of newly diagnosed DM in the Q2,Q3,Q4 is 1.480 times(95%CI 1.080~2.020,P=0.015),1.620 times(95%CI 1.190~2.220,P=0. 002),and 1. 630 times (95%CI 1. 180~2. 250,P=0. 003) higher than that in the Q1 respectively.Conclusions FLI is significantly associated with the risk of new onset DM in both NGT and IGRpopulations,and is an independent risk factor for newly diagnosed DM.

关 键 词：脂肪肝指数 糖尿病 危险因素 

分 类 号：R587.1[医药卫生—内分泌]