异基因造血干细胞移植术后侵袭性真菌感染的最新研究进展  

Research Progresson Invasive Fungal Infection after Allogeneic Hematopoietic Stem Cell Transplantation——Revi

作　　者：李忠玉 伍燕平 白雪 李佳佳 LI Zhong-Yu;WU Yan-Ping;BAI Xue;LI Jia-Jia(Department of Hematology,The First Affiliated Hospital of Bengbu Medical University,Bengbu 233000,Anhui Province,China)

机构地区：[1]蚌埠医科大学第一附属医院血液科,安徽蚌埠233000

出　　处：《中国实验血液学杂志》2024年第6期1937-1940,共4页Journal of Experimental Hematology

摘　　要：异基因造血干细胞移植术是血液系统恶性肿瘤的主要治疗方法之一,移植技术的不断完善和普及为恶性血液病患者延长生命、提高生存率带来了希望。术后合并侵袭性真菌感染是最常见的感染并发症,也是移植后患者死亡的主要原因,早期诊断困难,死亡率极高。本文就移植术后致侵袭性真菌感染的念珠菌、曲霉菌和毛霉菌的病原学类型、诊断方法、高危因素及治疗方案的最新研究进展作一综述,为提高移植术后合并侵袭性真菌感染的早期诊断率及治疗有效性提供参考。Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is one of the main treatment methods for hematological malignancies.With the continuous improvement and popularization of transplantation technology,it has brought hope for prolonging the lives and improving the survival rate of patients with hematological malignancies.However,postoperative invasive fungal infection(IFI)is the most common infectious complication and the main cause of death,with difficult early diagnosis and extremely high mortality.This paper summarizes the latest research progress on the pathogenic types,diagnostic methods,high-risk factors and treatment regimen of Candida,Aspergillus and Mucor associated with postoperative IFI,which is expected to provide references for improving the early diagnosis rate and treatment effectiveness of postoperative IFI.

关 键 词：异基因造血干细胞移植术 侵袭性真菌感染 病因学 诊断 治疗 

分 类 号：R457.7[医药卫生—治疗学]