急性腹泻患儿粪便病原微生物检验结果及耐药情况分析  

Analysis of the Results and Drug Resistance of Fecal Pathogenic Microorganisms in Children with Acute Diarrhea

作　　者：张磊[1] 仲华[2] 王朝辉[1] ZHANG Lei;ZHONG Hua;WANG Chao-hui(Clinical Laboratory,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,Henan Province,China;Blood Transfusion Department,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,Henan Province,China)

机构地区：[1]新乡医学院第一附属医院检验科,河南新乡453100 [2]新乡医学院第一附属医院输血科,河南新乡453100

出　　处：《罕少疾病杂志》2024年第11期103-105,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨急性腹泻患儿粪便病原微生物检验结果及耐药情况。方法选取2021年1月-2023年1月我院收治的167例急性腹泻患儿,采集所有患儿粪便标本送检,开展病原微生物培养与药敏试验。统计病原微生物检检验结果、分析急性病原微生物分布特点、志贺氏菌属、沙门氏菌属的耐药情况。结果167急性腹泻患儿共检出109株病原微生物,其中细菌51株(46.79%)、病毒48株(44.04%)、真菌10株(9.17%);51株细菌(46.79%)以志贺氏菌属(13.76%)、沙门氏菌(22.02%)、大肠埃希菌(4.59%)为主;48株病毒(44.04%),以轮状病毒(22.94%)、诺如病毒(15.60%)为主,真菌10株(9.17%);志贺氏菌属、沙门氏菌属对氨苄西林、哌拉西林、四环素的耐药性偏高,均>50%;对氨苄西林/舒巴坦、阿莫西林/克拉维酸、哌拉西林/他唑巴坦、头孢他啶、头孢吡肟、氯霉素、环丙沙星、左氧氟沙星、氨曲南的耐药性偏低,均﹤50%;对厄他培南、亚胺培南、美罗培南未产生耐药性。结论急性腹泻患儿粪便病原微生物以病毒、志贺氏菌属、沙门氏菌属、大肠埃希菌多见,临床需据此开展针对性治疗,以加快患者病情转归。Objective To explore the results of fecal pathogenic microbial testing and drug resistance in children with acute diarrhea.Methods A total of 167 children with acute diarrhea admitted to our hospital from January 2021 to January 2023 were selected,and stool samples of all children were collected for examination,and pathogenic Microbiological culture and drug sensitivity test were carried out.The results of pathogenic microorganism examination were counted,and the distribution characteristics of acute pathogenic microorganisms and the drug resistance of Shigella and Salmonella were analyzed.Results A total of 109 strains of pathogenic microorganisms were detected in 167 children with acute diarrhea,including 51 strains of bacteria(46.79%),48 strains of viruses(44.04%),and 10 strains of fungi(9.17%);51 strains of bacteria(46.79%)were mainly Shigella(13.76%),Salmonella(22.02%)and Escherichia coli(4.59%);48 strains of viruses(44.04%),mainly rotavirus(22.94%)and Norovirus(15.60%),and 10 strains of fungi(9.17%);the resistance of Shigella and Salmonella to ampicillin,Piperacillin and tetracycline was higher than 50%;the drug resistance to ampicillin/sulbactam,Amoxicillin/Clavulanic acid,Piperacillin/tazobactam,Ceftazidime,cefepime,Chloramphenicol,Ciprofloxacin,Levofloxacin,and aztreonam was lower than 50%;there was no resistance to Ertapenem,Imipenem and Meropenem.Conclusion Fecal pathogenic microorganisms in children with acute diarrhea are mainly viruses,Shigella,Salmonella and Escherichia coli.Sex therapy should be carried out according to this to accelerate the prognosis of patients.

关 键 词：急性腹泻 病原微生物 耐药情况 志贺氏菌属 沙门氏菌属 

分 类 号：R725.7[医药卫生—儿科]