Kege联合Bobath球训练对盆腔脏器脱垂盆底功能和血清MMP-2及TIMP-2水平的影响  

Effect of Kegel Combined with Bobath Ball Training on Pelvic Floor Function and Serum MMP-2 and TIMP-2 Levels in Patients with Pelvic Organ Prolapse

作　　者：刘艳 张佳 LIU Yan;ZHANG Jia(Department of Gynaecology,Anyang Maternal and Child Health Hospital,Anyang 455000,Henan Province,China)

机构地区：[1]安阳市妇幼保健院妇科,河南安阳455000

出　　处：《罕少疾病杂志》2024年第11期108-110,共3页Journal of Rare and Uncommon Diseases

基　　金：安阳市重点研发与推广专项(科技攻关)(20230225069)。

摘　　要：目的探讨Kegel联合Bobath球训练对盆腔脏器脱垂患者盆底功能和血清基质金属蛋白酶-2(MMP-2)及组织金属蛋白酶抑制剂-2(TIMP-2)水平的影响。方法本研究中共纳入112例盆腔脏器脱垂患者作为研究对象,所有患者均来源于河南省安阳市妇幼保健院,选取时间为2020年3月至2023年3月,将所有患者按照随机数字表法分为对照组(56例,常规干预措施)和研究组(56例,Kegel联合Bobath球训练)。两组患者均进行为期半年的干预。将两组患者干预前后盆底功能各项评分、盆底肌电生理指标、基质金属蛋白酶-2(MMP-2)、组织金属蛋白酶抑制剂-2(TIMP-2)指标水平,以及两组患者并发症发生情况进行对比。结果干预后两组患者盆底功能障碍影响问卷(PFIQ-7)、盆底功能障碍量表(PFDI-20)评分均相较于干预前下降,且研究组相较于对照组下降(均P<0.05);干预后两组患者Ⅰ类肌纤维疲劳度、Ⅰ类肌纤维肌电值等均相较于干预前上升,且研究组患者上述指标均相较于对照组上升(均P<0.05);干预后两组患者MMP-2指标水平均相较于干预前下降,且研究组相较于对照组下降,干预后两组患者TIMP-2指标水平均相较于干预前上升,且研究组相较于对照组上升(均P<0.05);研究组患者并发症总发生率为7.14%,相较于对照组的35.71%下降(P<0.05)。结论盆腔脏器脱垂患者应用Kegel联合Bobath球训练,有助于盆底功能、盆底肌电生理指标的改善,并通过对MMP-2、TIMP-2指标水平进行调控起到对损伤神经进行修复的作用,且安全性较高。Objective To investigate the effect of Kegel combined with Bobath ball training on pelvic floor function and serum levels of matrix metalloproteinase-2(MMP-2)and tissue metallo-proteinase inhibitor-2(TIMP-2)in patients with pelvic organ prolapse.Methods A total of 112 patients with pelvic organ prolapse were included in the study,and all patients were obtained from Maternal and child Health Hospital of Anyang City,Henan Province,selected from March 2020 to March 2023.All patients were divided into control group(56 cases,conventional intervention measures)and study group(56 cases,Kegel combined Bobath ball training).Both groups had a half-year intervention.The scores of pelvic floor function,pelvic floor muscle electrophysiological indicators,matrix metalloproteinase-2(MMP-2),tissue metalloproteinase inhibitor-2(TIMP-2),and the occurrence of complications between the two groups were compared.Results The pelvic floor dysfunction impact questionnaire(PFIQ-7),pelvic floor dysfunction scale(PFDI-20)score decreased after the intervention,Moreover,the study group decreased compared with the control group(all P<0.05);after the intervention,the fatigue degree of class I myofiber and class I electromyofiber value of patients in both groups increased compared with that before the intervention,Moreover,the above indicators in the study group increased compared with the control group(P<0.05);MMP-2 index levels decreased in both groups after intervention compared to pre-intervention,and the study group compared to the control group,TIMP-2 index levels increased in both groups compared to pre-intervention.Moreover,the study group increased compared with the control group(all P<0.05);the overall complication incidence of patients in the study group was 7.14%,Compared with the 35.71%decrease in the control group(P<0.05).Conclusion The patients with pelvic organ prolapse can help the improvement of pelvic floor function and pelvic floor muscle electrophysiological indexes,and regulate the level of MMP-2 and TIMP-2,and the safety i

关 键 词：Kegel Bobath球训练 盆腔脏器脱垂 盆底功能 基质金属蛋白酶-2 组织金属蛋白酶抑制剂-2 影响 

分 类 号：R711.2[医药卫生—妇产科学]