自体富血小板凝胶对烧伤创面修复作用及血清炎症因子水平的影响  

Effect of Autologous Platelet-rich Gel on Wound Repair and Serum Inflammatory Factor Levels in Burn Patients

作　　者：祝天华 郜天田 李小雪 ZHU Tian-hua;GAO Tian-tian;LI Xiao-xue(First Ward of Burn Department,Nanshi Hospital of Nanyang,Nanyang 473000,Henan Province,China)

机构地区：[1]南阳南石医院烧伤科一病区,河南南阳473000

出　　处：《罕少疾病杂志》2024年第11期135-136,142,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探究自体富血小板凝胶对烧伤患者创面修复作用及血清炎症因子水平的影响。方法选取2022年1月~2024年3月我院收治的90例烧伤患者作为研究对象。采用随机数字表法将其分为两组各45例。对照组(45例):封闭负压引流治疗。观察组(45例):对照组基础上给予自体富血小板凝胶干预。比较两组创面修复情况、瘢痕评分、血清炎症因子水平及并发症发生情况。结果观察组创面愈合时间、住院时间均短于对照组,肉芽生长面积小于对照组,差异显著(t=2.283、P=0.025,t=2.435、P=0.017,t=2.896、P=0.005)。观察组治疗2个月后的瘢痕评分低于对照组,差异显著(t=2.261,P=0.026)。治疗前,两组TNF-α、IL-6水平比较差异不显著(P>0.05),与治疗前相比,治疗后两组TNF-α、IL-6水平均降低(P<0.001),且观察组低于对照组,差异显著(t=3.570、P=0.001,t=2.427、P=0.017)。观察组皮肤瘙痒2例(4.44%),水肿1例(2.22%),渗出增多1例(2.22%),并发症总发生率为8.89%,对照组皮肤瘙痒2例(4.44%),水肿2例(4.44%),渗出增多1例(2.22%),感染1例(2.22%),并发症总发生率为13.33%,两组比较差异不显著(c2=0.450,P=0.502)。结论自体富血小板凝胶可促进烧伤患者的创面修复,减少瘢痕增生,减轻炎症反应,且并发症少,安全性高。Objective To investigate the effect of autologous platelet-rich gel on wound repair and serum inflammatory factors in burn patients.Methods 90 burn patients treated in our hospital from January 2022 to March 2024 were selected as the study objects.They were divided into two groups with 45 cases in each group by random number table method.Control group(45 cases):closed negative pressure drainage treatment.Observation group(45 cases):control group was given autologous platelet rich gel intervention.Wound repair,scar score,serum inflammatory factor levels and complications were compared between the two groups.Results The wound healing time and hospital stay in the observation group were shorter than those in the control group,and the area of granulation growth was smaller than that in the control group,the difference was significant(t=2.283,P=0.025,t=2.435,P=0.017,t=2.896,P=0.005).After 2 months of treatment,the scar score of the observation group was lower than that of the control group,and the difference was significant(t=2.261,P=0.026).Before treatment,there was no significant difference in the levels of TNF-αand IL-6 between the two groups(P>0.05).Compared with before treatment,the levels of TNF-αand IL-6 in the two groups were decreased after treatment(P<0.001),and the observation group was lower than the control group,the difference was significant(t=3.570,P=0.001,t=2.427,P=0.017).In the observation group,there were 2 cases of pruritus(4.44%),1 case of edema(2.22%),1 case of increased exudation(2.22%),and the total complication rate was 8.89%;in the control group,there were 2 cases of pruritus(4.44%),2 cases of edema(4.44%),1 case of increased exudation(2.22%),and 1 case of infection(2.22%).The total incidence of complications was 13.33%,and there was no significant difference between the two groups(χ^(2)=0.450,P=0.502).Conclusion Autologous platelet-rich gel can promote wound repair in burn patients,reduce scar hyperplasia,relieve inflammation,and have fewer complications and high safety.

关 键 词：自体富血小板凝胶 烧伤 创面修复 炎症因子 

分 类 号：R644[医药卫生—外科学]