猪细小病毒感染引起宿主信号通路变化的研究进展  

Research progress on alterations in host signaling pathways triggered by porcine parvovirus infection

作　　者：周敏 汤德元[1] 曾智勇[1] 王彬[1] 黄涛[1] 胡雯雯 毛茵茗 周飘 何松 ZHOU Min;TANG Deyuan;ZENG Zhiyong;WANG Bin;HUANG Tao;HU Wenwen;MAO Yinming;ZHOU Piao;HE Song(College of Animal Science,Guizhou University,Guiyang 550025,China)

机构地区：[1]贵州大学动物科学学院,贵州贵阳550025

出　　处：《中国兽医学报》2024年第10期2294-2300,共7页Chinese Journal of Veterinary Science

基　　金：黔科合平台人才资助项目([2018]5781-8);国家自然科学基金资助项目(31860716)。

摘　　要：猪细小病毒(porcine parvovirus,PPV)是猪细小病毒病(porcine parvovirus infection,PPI)的病原体,感染PPV是引起猪繁殖障碍的重要原因,给养猪业带来严重危害。本病临床以妊娠母猪产死胎、木乃伊胎、弱胎和发生流产等为特征,其发病机制尚未被完全了解,且目前尚无有效的治疗药物。近年来,人们已对PPV感染宿主后其信号通路变化做了大量地深入研究,许多相应的信号通路传导机制也已发现,但仍缺乏对其系统性的探究,通过对PPV感染后引起的相关信号通路变化的研究进行综述,以期为研究PPV的致病机制和新型药物开发提供新的思路。Porcine parvovirus(PPV)is a causative agent of porcine parvovirus infection(PPI),which significantly impacts the pig industry due to its association with reproductive dysfunction.The condition is characterized by stillbirth,mummified fetuses,fetal weakness,and abortion in pregnant sows.The pathogenic mechanism remains incompletely understood,with no effective therapeutic drugs available currently.Despite extensive research on the host's response to PPV infection and identification of various signaling pathway transduction mechanisms,a comprehensive understanding is still lacking.This review aims to summarize the current knowledge regarding alterations in related signaling pathways following PPV infection,provide novel insights into the pathogenesis of PPV and facilitate the drug development.

关 键 词：猪细小病毒 繁殖障碍 信号通路 致病机制 

分 类 号：S852.2[农业科学—基础兽医学] S852.65[农业科学—兽医学]