克林霉素甲硝唑搽剂联合阿达帕林治疗寻常痤疮患者的临床研究  

Clinical trial of clindamycin hydrochloride and meteonidazole liniment combined with adapalene in the treatment of patients with acne vulgaris

作　　者：丁文 李玉萍[2] DING Wen;LI Yu-ping(School of Traditional Chinese Medicine,Anyang Vocational and Technical College,Anyang 455000,Henan Province,China;Dermatology Department,Anyang City People’s Hospital,Anyang 455000,Henan Province,China)

机构地区：[1]安阳职业技术学院中医药学院,河南安阳455000 [2]安阳市人民医院皮肤科,河南安阳455000

出　　处：《中国临床药理学杂志》2024年第21期3087-3091,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察克林霉素甲硝唑搽剂联合阿达帕林凝胶治疗寻常痤疮患者的临床疗效及安全性。方法将寻常痤疮患者按照队列法分为对照组和试验组。对照组患者给予阿达帕林凝胶治疗,睡前于患处薄涂,qd。在对照组的基础治疗上,试验组患者给予克林霉素甲硝唑搽剂治疗,清晨于患处涂抹,qd。2组患者均治疗4周。比较2组患者的临床疗效、皮损程度、痤疮瘢痕评估量表(ECCA)权重评分、皮肤病生活质量指数(DLQI)评分、皮肤屏障功能、随访6个月的复发率及安全性。结果试验组和对照组分别入组46例和54例。治疗4周后,试验组和对照组的总有效率分别为93.48%(43例/46例)和79.63%(43例/54例),在统计学上差异有统计学意义(P<0.05)。治疗4周后,试验组和对照组的非炎性皮损数目分别为(8.60±1.83)和(11.24±2.06)个,炎性皮损数目分别为(5.19±1.04)和(7.48±1.51)个,ECCA权重评分分别为(23.38±2.86)和(27.96±5.42)分,DLQI评分分别为(6.22±1.17)和(9.42±1.54)分,表皮水分丢失量(TEWL)分别为(17.17±3.39)和(21.46±3.83)g·hm^(-2),角质层含水量分别为(49.53±9.37)和(45.82±7.96)Acu,皮脂含量分别为(57.46±6.65)和(61.09±5.47);随访6个月,试验组和对照组的复发率分别为2.17%(1例/46例)和14.81%(8例/54例);试验组的上述指标与对照组比较,在统计学上差异均有统计学意义(均P<0.05)。试验组的药物不良反应主要有皮肤轻度灼烧或刺痛、皮肤干燥,对照组的药物不良反应主要有皮肤轻度灼烧或刺痛。试验组和对照组的总药物不良反应发生率分别为10.87%(5例/46例)和7.41%(4例/54例),在统计学上差异无统计学意义(P>0.05)。结论克林霉素甲硝唑搽剂联合阿达帕林凝胶治疗寻常痤疮患者的临床疗效显著,可以有效减少瘢痕形成,促进患者皮肤屏障功能恢复,改善患者生活质量,并降低复发率,且安全性较好。Objective To observe the clinical efficacy and safety of clindamycin metronidazole liniment combined with adapalene gel in the treatment of acne vulgaris.Methods Patients with acne vulgaris were divided into control group and treatment group by cohort methed.The control group thinly applied adapalene gel(once a day)to the affected area before going to bed.On the basis of the control group,the treatment group applied clindamycin hydrochloride and meteonidazole liniment(once a day)to the affected area every morning.Both groups were treated for 4 weeks.The clinical efficacy,degree of skin lesions,echelle d'evaluation clinique des cicatrices d'acne(ECCA)weight score,Dermatology Life Quality Index(DLQI)score,skin barrier function,recurrence rate at 6 months of follow-up and adverse drug reactions during medication were compared.Results Forty-six cases in treatment group and fifty-four cases in control group were enrolled.After 4 weeks of treatment,the total effective rates in treatment group and control group were 93.48%(43 cases/46 cases)and 79.63%(43 cases/54 cases),the number of non-inflammatory lesions were 8.60±1.83 and 11.24±2.06;the number of inflammatory lesions were 5.19±1.04 and 7.48±1.51;the ECCA weight scores were(23.38±2.86)and(27.96±5.42)points;the DLQI scores were(6.22±1.17)and(9.42±1.54)points;the transepidermal water loss(TEWL)values were(17.17±3.39)and(21.46±3.83)g·hm^(-2);the water contents of stratum corneum were(49.53±9.37)and(45.82±7.96)Acu;the sebum contents were 57.46±6.65 and 61.09±5.47;the recurrence rates at 6 months of follow-up were 2.17%(1 case/46 cases)and 14.81%(8 cases/54 cases);there were statistically significant differences in the above indexes between the experimental group and the control group(all P<0.05).The adverse drug reactions in treatment group were mainly mild burning or stinging skin,dry skin,and the adverse drug reactions in control group were mainly mild burning or stinging skin.The total incidences of adverse drug reactions in treatment group and control

关 键 词：克林霉素甲硝唑搽剂 阿达帕林凝胶 寻常痤疮 临床疗效 痤疮瘢痕评估量表权重评分 皮肤屏障功能 

分 类 号：R978[医药卫生—药品]