中医药调控p38-MAPK信号通路在心力衰竭心肌纤维化中的研究现状  

Research status on the regulation of the p38-MAPK signaling pathway in myocardial fibrosis of heart failure using traditional Chinese medicine

作　　者：王一博 沙万敏 秦亚录 魏华[3] 毛琪玥 王言 WANG Yi-bo;SHA Wan-min;QIN Ya-lu;WEI Hua;MAO Qi-yue;WANG Yan(Clinical Medical College,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;Department of Cardiology,No.3 Affiliated Hospital of Chengdu University of Traditional Chinese Medicine/Chengdu Pidu District Hospital of Traditional Chinese Medicine,Chengdu 611730,Sichuan Province,China;Department of Pulmonary Diseases,No.3 Affiliated Hospital of Chengdu University of Traditional Chinese Medicine/Chengdu Pidu District Hospital of Traditional Chinese Medicine,Chengdu 611730,Sichuan Province,China)

机构地区：[1]成都中医药大学临床医学院,四川成都610075 [2]成都中医药大学附属第三医院/成都市郫都区中医医院心内科,四川成都611730 [3]成都中医药大学附属第三医院/成都市郫都区中医医院肺病科,四川成都611730

出　　处：《中国临床药理学杂志》2024年第21期3167-3170,共4页The Chinese Journal of Clinical Pharmacology

基　　金：四川省中医药管理局科研基金资助项目(2023MS046);四川省医学会医学科研青年创新课题资助项目(Q21091);成都市医学科研课题资助项目(2021259)。

摘　　要：在心力衰竭(HF)发展进程中,p38-丝裂原激活蛋白激酶(MAPK)的过度表达被认为是导致心肌纤维化(MF)的关键通路。中药活性成分、中药复方及中成药通过调控p38-MAPK在防治胶原蛋白积累、抑制心肌纤维化进程、改善心力衰竭程度、提升心功能等方面都具有显著优势。本文通过总结近年来中医药在p38-MAPK信号通路治疗HF MF方面的相关研究成果,旨在为HF MF的预防和治疗上提供新的潜在作用靶点。The over expression of p38-mitogen-activated protein kinase(MAPK)is considered a crucial pathway leading to myocardial fibrosis(MF)in the development of heart failure(HF).Traditional Chinese medicine active ingredients,compounds,and patent medicines have significant advantages in preventing and treating collagen accumulation,inhibiting the process of myocardial fibrosis,improving the degree of heart failure,and enhancing cardiac function by regulating p38-MAPK.This article summarizes recent research on traditional Chinese medicine’s treatment of HF MF through the p38-MAPK signaling pathway with the aim to provide new potential targets for preventing and treating HF MF.

关 键 词：中医药 p38-丝裂原激活蛋白激酶信号通路 心力衰竭 心肌纤维化 

分 类 号：R28[医药卫生—中药学]